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Clinicopathologic Reports, Case Reports, and Small Case Series |

Spontaneous Anterior Capsular Rupture Associated With Anterior Polar Cataract FREE

Juan G. Gaviria, MD; Daniel A. Johnson, MD; Frank W. Scribbick III, MD; Mark J. Gallardo, MD
[+] Author Affiliations

Section Editor: W. Richard Green, MD

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Arch Ophthalmol. 2006;124(1):134-135. doi:10.1001/archopht.124.1.134.
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Published online

Lens capsular rupture has been reported to be traumatic or spontaneous. Traumatic capsular ruptures can occur from penetrating,1 surgical,2,3 or blunt trauma.4 Spontaneous capsular rupture has been described after cataract extraction in the fellow eye5 and associated with hypermature cataracts.6

To our knowledge, there have been no reports of spontaneous anterior capsular rupture causing lens-induced uveitis in the setting of anterior polar cataracts. We report the case of a 59-year-old woman with long-standing anterior polar cataract who developed spontaneous capsular rupture and lens-induced uveitis.

A 59-year-old white woman complained of recurrent episodes of pain and photophobia in the left eye. The last episode was 1 year prior to initial examination, during which time she was diagnosed as having anterior uveitis and treated with topical steroids. Her ocular history was notable for a congenital polar cataract diagnosed early in childhood and amblyopia in the affected left eye. She had no history of trauma or ocular surgery. Her medical history included controlled type 2 diabetes mellitus and hypertension but was otherwise unremarkable.

When seen at the University of Texas Health Science Center at San Antonio Cornea and Uveitis Service, her best-corrected visual acuity was 20/80 OS. Ophthalmic examination revealed a white mass protruding on the anterior lens capsule adjacent to the anterior polar cataract (Figures 1, 2, and 3). The remainder of the lens showed 1 to 2+ nuclear sclerosis. Flare and cells (2+) were present in the anterior chamber, but there was no fibrin or hypopyon. Guttata and pigment were present in the endothelium of both eyes. Uveitis evaluation was noncontributory.

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Figure 1.

Anteroposterior slitlamp photograph of the anterior polar cataract.

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Figure 2.

Gonioscopic view of the anterior cortex protruding through the capsular opening.

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Figure 3.

Slitlamp photograph of the protruding cortex in the anterior chamber.

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Hourly 1% prednisolone acetate and once daily 1% atropine were prescribed. The anterior uveitis resolved in 26 days, and phacoemulsification without intraocular lens implantation was performed 5 weeks after initial examination. During surgery, the anterior capsule and anterior polar cataract were recovered. At the end of surgery, a sub-Tenon injection of 40 mg of triamcinolone acetonide was administered in the inferonasal quadrant.

The capsular specimen was fixed in 10% formaldehyde and stained with hematoxylin-eosin. The presence of a break in the anterior capsule, through which the cortical material was protruding, was confirmed histologically (Figure 4). Aside from a few isolated pigment-containing macrophages, no neutrophils, eosinophils, or other inflammatory cells were present at the site of the capsular break.

Place holder to copy figure label and caption
Figure 4.

Hematoxylin-eosin low-power light microscopy of the anterior lens. The solid arrows point to the thinning edges of the capsule at the site of rupture. The central dashed arrow is pointing to the anterior subcapsular cataract. Cortical material is seen between the capsular edges.

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One month postoperatively, the eye continued to be quiet and topical steroids were tapered until administration was discontinued. Five months’ postoperatively, the patient obtained a visual acuity of 20/30 OS with a +8.50-diopter contact lens. At this time, both eyes were quiet during slitlamp examination.

Lens-induced uveitis has been recognized since 1919 by Straub7 and later by Verhoeff and Lemoine.8 The condition is traditionally explained by rupture of the lens capsule either by trauma or spontaneously; the latter is usually related to the presence of hypermature cataracts. To our knowledge, spontaneous capsular rupture causing lens-induced uveitis in the setting of anterior polar cataract has not been described.

Definitive treatment for lens-induced uveitis is cataract extraction.9 Intracapsular cataract extraction has been the proposed method for treatment of phacogenic uveitis associated with hypermature cataracts9 to avoid the protein exposure resulting from extracapsular techniques. This technique, however, precludes capsular-based intraocular lens fixation. In patients with uveitis, surgery is considered safer when there has been control of the inflammation for at least 3 months.10 In our patient with lens-induced uveitis, however, we performed phacoemulsification promptly once the uveitis was quiet. Although primary posterior chamber intraocular lens insertion may have been reasonable,11 we decided against it, knowing that some patients can develop chronic intractable intraocular inflammation requiring lens removal to quiet the eye and prevent irreversible damage.12

Our diagnosis of lens-induced uveitis was confirmed histopathologically by the presence of a break in the anterior capsule. The absence of inflammatory cells within the substance of the specimen can be explained by the topical use of hourly prednisolone acetate prior to surgery.

We believe our case is the first report of spontaneous capsular rupture in the setting of anterior polar cataract, causing moderate lens-induced uveitis. This patient’s uveitis was successfully treated by cataract extraction and local steroids. Visual rehabilitation was achieved with a contact lens.

Correspondence: Dr Gaviria, Department of Ophthalmology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, MSC 6230, San Antonio, TX 78229 (juangaviria@lycos.com).

Financial Disclosure: None.

Funding/Support: This study was supported in part by an unrestricted grant from Research to Prevent Blindness, Inc, New York, NY.

Acknowledgment: We wish to thank Paul Comeau, CRA, for taking the slitlamp photographs and Peggy Miller, HT(ASCP), for her help with histological examination.

Perlman  EMAlbert  DM Clinically unsuspected phacoanaphylaxis after ocular trauma Arch Ophthalmol 1977;95244- 246
PubMed
Margo  CEMcKnight  GT Lens-induced granulomatous uveitis following trabeculectomy. Arch Ophthalmol 1988;1061035
PubMed
Apple  DJMamalis  NSteinmetz  RL  et al.  Phacoanaphylactic endophthalmitis associated with extracapsular cataract extraction and posterior chamber intraocular lens. Arch Ophthalmol 1984;1021528- 1532
PubMed
Zabriskie  NA Anterior lens capsule rupture caused by airbag trauma. Am J Ophthalmol 1997;123832- 833
PubMed
Allen  JCde Venecia  G Spontaneous lens capsule rupture with uveitis. Am J Ophthalmol 1969;67144- 149
PubMed
Scott  JG Spontaneous rupture of the lens capsule. Br J Ophthalmol 1953;3758- 60
PubMed
Woods  AC An adventure in ophthalmic literature: Manuel Straub and the tradition of toxicity in lens protein. Am J Ophthalmol 1959;48463- 472
PubMed
Verhoeff  FHLemoine  AN Hypersensitiveness to lens protein: patient desensitized and successfully operated on for mature cataract. Am J Ophthalmol 1922;5700- 702
Marak  G Phacoanaphylactic endophthalmitis. Surv Ophthalmol 1992;36325- 339
PubMed
Foster  CSVitale  AT Therapeutic surgery: cornea, iris, cataract, glaucoma, vitreous, retina. In:Foster  CSed. Diagnosis and Treatment of Uveitis  Philadelphia, Pa WB Saunders2002;222- 235
Foster  RELowder  CYMeisler  DMZakov  ZN Extracapsular cataract extraction and posterior chamber intraocular lens implantation in uveitis patients. Ophthalmology 1992;991234- 1242
PubMed
Foster  CSStavrou  PZafirakis  P  et al.  Intraocular lens removal in patients with uveitis. Am J Ophthalmol 1999;12831- 37
PubMed

Figures

Place holder to copy figure label and caption
Figure 1.

Anteroposterior slitlamp photograph of the anterior polar cataract.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Gonioscopic view of the anterior cortex protruding through the capsular opening.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 3.

Slitlamp photograph of the protruding cortex in the anterior chamber.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 4.

Hematoxylin-eosin low-power light microscopy of the anterior lens. The solid arrows point to the thinning edges of the capsule at the site of rupture. The central dashed arrow is pointing to the anterior subcapsular cataract. Cortical material is seen between the capsular edges.

Graphic Jump Location

Tables

References

Perlman  EMAlbert  DM Clinically unsuspected phacoanaphylaxis after ocular trauma Arch Ophthalmol 1977;95244- 246
PubMed
Margo  CEMcKnight  GT Lens-induced granulomatous uveitis following trabeculectomy. Arch Ophthalmol 1988;1061035
PubMed
Apple  DJMamalis  NSteinmetz  RL  et al.  Phacoanaphylactic endophthalmitis associated with extracapsular cataract extraction and posterior chamber intraocular lens. Arch Ophthalmol 1984;1021528- 1532
PubMed
Zabriskie  NA Anterior lens capsule rupture caused by airbag trauma. Am J Ophthalmol 1997;123832- 833
PubMed
Allen  JCde Venecia  G Spontaneous lens capsule rupture with uveitis. Am J Ophthalmol 1969;67144- 149
PubMed
Scott  JG Spontaneous rupture of the lens capsule. Br J Ophthalmol 1953;3758- 60
PubMed
Woods  AC An adventure in ophthalmic literature: Manuel Straub and the tradition of toxicity in lens protein. Am J Ophthalmol 1959;48463- 472
PubMed
Verhoeff  FHLemoine  AN Hypersensitiveness to lens protein: patient desensitized and successfully operated on for mature cataract. Am J Ophthalmol 1922;5700- 702
Marak  G Phacoanaphylactic endophthalmitis. Surv Ophthalmol 1992;36325- 339
PubMed
Foster  CSVitale  AT Therapeutic surgery: cornea, iris, cataract, glaucoma, vitreous, retina. In:Foster  CSed. Diagnosis and Treatment of Uveitis  Philadelphia, Pa WB Saunders2002;222- 235
Foster  RELowder  CYMeisler  DMZakov  ZN Extracapsular cataract extraction and posterior chamber intraocular lens implantation in uveitis patients. Ophthalmology 1992;991234- 1242
PubMed
Foster  CSStavrou  PZafirakis  P  et al.  Intraocular lens removal in patients with uveitis. Am J Ophthalmol 1999;12831- 37
PubMed

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