Newly diagnosed patients with IMT were examined consecutively in the private offices of Vitreous-Retina-Macula Consultants of New York, New York, and at the LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, from January 1, 2002, through December 31, 2004. The office sites included primary centers such as the hospital clinics, a secondary referral private retinal practice in Brooklyn, New York, and a mixed retinal facility that was partially a tertiary referral practice in Manhattan, New York. Only patients examined for the first time who had a diagnosis made or confirmed were included. The study patients in the first 2 years were identified retrospectively; in the last year, they were recruited prospectively. A careful history on related systemic diseases, specifically systemic hypertension, diabetes mellitus, and radiation therapy to the head, was obtained from each patient. A full clinical examination, including indirect ophthalmoscopy and slitlamp biomicroscopy with the Goldmann contact lens, was performed. Digital fundus photography, digital fluorescein angiography (FA), and OCT were carried out for all of the patients.