Compared with other treatments, PDT has the theoretical advantage of selectively occluding the CNV, even in the presence of small amounts of overlying blood, without causing significant damage to the unaffected retina and choroid. Thus, PDT has the potential for vision improvement, especially in younger patients as shown in our cases. Furthermore, only a single treatment was necessary in both of these cases, unlike the 3 to 4 treatments routinely needed during the first year in patients with neovascular age-related macular degeneration.4 The decreased need for retreatment with PDT in these toxoplasmosis cases is similar to the retreatment rate observed in younger patients with postinflammatory CNV. While improvement could have occurred without PDT, these lesions were not in the process of resolving as suggested by the duration and progression of vision loss and the presence of new hemorrhages. Photodynamic therapy was most likely responsible for the observed improvements owing to the temporal relationship between treatment and the resolution of the CNV. To our knowledge, this is the second report of CNV secondary to toxoplasmosis treated with PDT5; the first report demonstrating a sustained visual acuity benefit from a single treatment with PDT, and the first successful use of PDT to treat a predominantly hemorrhagic lesion.