A 68-year-old woman was referred for the evaluation of an iris lesion in the left eye (Figure 1). Three weeks before our evaluation, she developed unilateral decreased vision. On examination, corrected visual acuity was 20/100 with no improvement with pinhole. A small hyphema was present in the anterior chamber. At the 5-o’clock meridian, there was a 2.5 × 1.6-mm, raised, vascular, nonpigmented mass on the iris, extending into the angle. The remainder of the eye examination results were unremarkable. Gonioscopy revealed several small, pale nodules in the inferior iridocorneal angle, separate from the main lesion. The patient underwent a diagnostic iridotrabeculectomy. Pathology specimens showed a spindle-type malignant melanoma of the iris as well as a melanoma nodule involving the adjacent iridocorneal angle tissue (Figure 2). Immunohistochemical staining for VEGF was positive using a rabbit antibody directed against human VEGF (Laboratory Vision Corporation/NeoMarkers, Fremont, Calif) (Figure 3).