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Correspondence |

No Association Between Variations in the WDR36 Gene and Primary Open-Angle Glaucoma

John H. Fingert, MD, PhD; Wallace L. M. Alward, MD; Young H. Kwon, MD, PhD; Suma P. Shankar, MD, PhD; Jeaneen L. Andorf, BA; David A. Mackey, MD, FRANZCO; Val C. Sheffield, MD, PhD; Edwin M. Stone, MD, PhD
Arch Ophthalmol. 2007;125(3):434-436. doi:10.1001/archopht.125.3.434-b.
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Glaucoma is the second-leading cause of permanent blindness in developed nations.1 Of the many forms of glaucoma, primary open-angle glaucoma (POAG) is the most common. Primary open-angle glaucoma is a clinically defined condition that is actually a collection of distinct diseases that are all characterized by a progressive optic nerve degeneration associated with insidious loss of visual field. There is a significant genetic contribution to the pathogenesis of POAG, and several loci associated with POAG have been mapped (GLC1A, chromosome 1q24.3-q25.22; GLC1B, chromosome 2cent-q133; GLC1C, chromosome 3q21-244; GLC1D, chromosome 8q235; GLC1E, chromosome 10p15-p146; and GLC1F, chromosome 7q35-q367). Glaucoma genes have been identified at the GLC1A8 and GLC1E9 loci.

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