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Clinical Trials |

Stability of Visual Acuity Improvement Following Discontinuation of Amblyopia Treatment in Children Aged 7 to 12 Years

Arch Ophthalmol. 2007;125(5):655-659. doi:10.1001/archopht.125.5.655.
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Objective  To assess the stability of visual acuity improvement during the first year after cessation of amblyopia treatment other than spectacle wear in children aged 7 to 12 years.

Methods  At the completion of a multicenter randomized trial during which amblyopia treated with patching and atropine improved by at least 2 lines on the electronic Early Treatment of Diabetic Retinopathy Study testing protocol, 80 patients aged 7 to 12 years were followed up while not receiving treatment (other than spectacle wear) for 1 year.

Main Outcome Measure  Ten letters or more (≥2 lines) worsening of visual acuity (measured using the electronic Early Treatment of Diabetic Retinopathy Study testing protocol) during the year following treatment discontinuation.

Results  During the year following cessation of treatment, the cumulative probability of worsening visual acuity (≥2 lines) was 7% (95% confidence interval, 3%-17%); 82% of patients maintained an increase in visual acuity of 10 letters or more compared with their visual acuity before starting treatment.

Conclusion  Visual acuity improvement occurring during amblyopia treatment is sustained in most children aged 7 to 12 years for at least 1 year after discontinuing treatment other than spectacle wear.

Trial Registration  clinicaltrials.gov Identifier: LOCATOR="http://clinicaltrials.gov/show/NCT00094692">NCT00094692

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Figure.

The plots include 67 patients who completed the observation phase, defined as completing 1 year of follow-up or experiencing a decrease in visual acuity of 10 letters or more during the follow-up period. For the one patient who experienced a decrease in visual acuity of 10 letters or more prior to the 1-year visit, the 1-year acuity is the acuity at the time of the decrease. A letter score of 85 corresponds to 20/20, with 5 letters representing 1 line. Lower letter scores indicate worse visual acuity. A, Visual acuity at treatment discontinuation vs visual acuity at 1 year after treatment discontinuation. B, Visual acuity before treatment vs visual acuity at 1 year after treatment discontinuation.

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