The compassionate off-label use of bevacizumab as well as the potential risks, benefits, and adverse effects of this medication were discussed extensively with each patient. The goal of treatment was to reduce corneal NV to improve the prognosis of future corneal transplantation. To further minimize systemic absorption, silicone punctal plugs were placed in the lower eyelids. The Duke University Hospital pharmacy assisted with the topical formulation of bevacizumab, which consisted of the intravenous solution (25 mg/mL) mixed with stock benzalkonium chloride solution, 0.5% (5 mg/mL), and sterile saline. The final formulation provided 5 mL of bevacizumab, 1.0% (10 mg/mL), with a 0.01% concentration of benzalkonium chloride (0.1 mg/mL) and a pH of 6.2. The patients applied topical bevacizumab, 1%, 4 times a day. All concurrent therapies were discontinued for at least 6 months prior to initiation of topical bevacizumab therapy. The patients were examined at 3 days, 1 week, 2 weeks, and 25 days after initiation of treatment. Slitlamp examination, tonometry, systemic blood pressure measurement, and slitlamp photography were completed at all visits.