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Clinicopathologic Reports, Case Reports, and Small Case Series |

Transient Homonymous Hemianopia and Positive Visual Phenomena in Patients With Nonketotic Hyperglycemia FREE

Mehryar Taban, MD; Richard I. Naugle, PhD; Michael S. Lee, MD
[+] Author Affiliations

Section Editor: W. Richard Green, MD

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Arch Ophthalmol. 2007;125(6):845-847. doi:10.1001/archopht.125.6.845.
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Homonymous hemianopic visual field defects usually result from structural processes affecting retrochiasmal visual pathways. Cranial magnetic resonance imaging typically identifies the responsible lesions. Etiologies of homonymous hemianopias and normal neuroimaging include the Heidenhain variant of Creutzfeldt-Jakob disease, the visual variant of Alzheimer disease, occipital or global ischemia/hypoxia, MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes), anemia, migraine, occipital seizures, functional illness, and nonketotic hyperglycemia (NKH).1 Herein, we report a case of transient homonymous hemianopia and positive visual symptoms caused by NKH and review the literature on this rare phenomenon.

REPORT OF A CASE

A 68-year-old man had well-controlled type 2 diabetes mellitus (blood glucose levels consistently 90-130 mg/dL [5.00-7.22 mmol/L]). His physician changed his medication to insulin glargine in early December 2004, which resulted in poorly controlled blood glucose levels that were consistently more than 600 mg/dL (33.31 mmol/L) until early January. He developed intermittent photopsias, visual hallucinations, and “distorted” vision OU in the middle of December 2004. He denied having any other visual or neurologic symptoms.

Visual acuities were 20/50 OD and 20/40 OS. Automated perimetry revealed a complete left homonymous hemianopia (Figure 1). The rest of his neuro-ophthalmic examination findings were unremarkable except for nuclear sclerosis in the right eye and scleral buckle in the left.

Place holder to copy figure label and caption
Figure 1.

Thirty degree Humphrey visual fields of left eye (A) and right eye (B). Note a dense left homonymous hemianopia is present during the period of uncontrolled hyperglycemia.

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Cranial magnetic resonance imaging (including diffusion-weighted imaging, fluid attenuated inversion recovery, and gadolinium) and single-photon emission computed tomography scans showed normal results. Neuropsychological test results were unremarkable. His blood glucose levels improved to 100 to 150 mg/dL (5.55-8.33 mmol/L) and the hallucinations resolved 1 week later. At 2-week follow-up, automated perimetry showed resolution of the homonymous hemianopia (Figure 2). Electroencephalogram was not obtained given the prompt resolution of symptoms after blood glucose levels improved.

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Figure 2.

Thirty degree Humphrey visual fields of left eye (A) and right eye (B). Note resolution of the visual field defect after correction of hyperglycemia.

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COMMENT

“Stroke mimics” are unusual manifestations of nonvascular conditions that may resemble acute stroke symptoms and may result from metabolic, psychiatric, and central nervous system disorders (seizure, complicated migraine, tumor, myasthenia, and multiple sclerosis). Metabolic disorders represent a small subgroup (0.7% of mimics) of potentially treatable causes of acute focal neurological deficits.2 They include hypoglycemia, hyperglycemia, hyponatremia, hypoxia, uremia, and hepatic encephalopathy.

Seizures have been reported in 25% of patients with NKH; published reports emphasize partial motor seizures almost exclusively.3 However, other clinical manifestations include hallucinations, myotonic twitches, nystagmus, tonic eye deviations, hemiparesis, hemisensory defect, aphasia, and homonymous hemianopia.3,4

The patient herein developed transient homonymous hemianopia and positive visual phenomena secondary to NKH. We found only 7 other cases in the literature (Table). The average blood glucose level was 538 mg/dL (29.86 mmol/L) with a minimum of 343 mg/dL (19.04 mmol/L). There were 5 men and 3 women. All but 1 were older than 55 years of age. Half of the cases experienced visual symptoms only. The symptoms all resolved within days of controlling the blood glucose level. Although not completely understood, the pathophysiologic mechanism in some cases may occur from underlying seizure activity, as evidenced by electroencephalogram abnormalities.

Table Graphic Jump LocationTable. Patients With Transient Homonymous Hemianopia and Positive Visual Phenomena Secondary to Nonketotic Hyperglycemia

When glucose concentration rises, water is osmotically attracted from the intracellular fluid space, resulting in cellular dehydration, alteration of enzyme activity, and subsequent neuronal dysfunction.3,4 Additionally, most patients with focal seizures in NKH are elderly and may have cerebral areas with borderline vascular supply. Given the stresses of hyperosmolality, incipient vascular ischemia in an area of borderline perfusion leads to cellular anoxia, clinically manifested in focal neurological deficits and focal seizures. This interaction between an area of potential dysfunction and the epileptogenic effect of hypertonic glucose solutions has been experimentally demonstrated.3,4 In keeping with this hypothesis, Maccario4 reported a recurrence of stereotypic neurological symptoms with hyperglycemia.

In conclusion, NKH should be considered in patients with homonymous hemianopia, positive visual phenomena, and negative neuroimaging studies. The mechanism is not completely understood but may represent ictal or postictal inhibition.

ARTICLE INFORMATION

Correspondence: Dr Lee, Department of Ophthalmology, University of Minnesota, 420 Delaware St, MMC 493, Minneapolis, MN 55455 (leex2679@umn.edu).

Financial Disclosure: None reported.

REFERENCES

Brazis  PWLee  AGGraff-Radford  N  et al.  Homonymous visual field defects in patients without corresponding structural lesions on neuroimaging. J Neuroophthalmol 2000;2092- 96
PubMed Link to Article
Berkovic  SFBladin  PFDarby  DG Metabolic disorders presenting as stroke. Med J Aust 1984;140421- 424
PubMed
Prockop  LD Hyperglycemia: effect on the nervous system. Handbook of Clinical Neurology 1976;2779- 98
Maccario  M Neurological dysfunction associated with nonketotic hyperglycemia. Arch Neurol 1968;19525- 534
PubMed Link to Article
Freedman  KAPolepalle  S Transient homonymous hemianopia and positive visual phenomena in nonketotic hyperglycemic patients. Am J Ophthalmol 2004;1371122- 1124
PubMed Link to Article
Harden  CLRosenbaum  DHDaras  M Hyperglycemia presenting with occipital seizures. Epilepsia 1991;32215- 220
PubMed Link to Article
Johnson  SFLoge  RV Palinopsia due to nonketotic hyperglycemia. West J Med 1988;148331- 332
PubMed

Figures

Place holder to copy figure label and caption
Figure 1.

Thirty degree Humphrey visual fields of left eye (A) and right eye (B). Note a dense left homonymous hemianopia is present during the period of uncontrolled hyperglycemia.

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Place holder to copy figure label and caption
Figure 2.

Thirty degree Humphrey visual fields of left eye (A) and right eye (B). Note resolution of the visual field defect after correction of hyperglycemia.

Graphic Jump Location

Tables

Table Graphic Jump LocationTable. Patients With Transient Homonymous Hemianopia and Positive Visual Phenomena Secondary to Nonketotic Hyperglycemia

References

Brazis  PWLee  AGGraff-Radford  N  et al.  Homonymous visual field defects in patients without corresponding structural lesions on neuroimaging. J Neuroophthalmol 2000;2092- 96
PubMed Link to Article
Berkovic  SFBladin  PFDarby  DG Metabolic disorders presenting as stroke. Med J Aust 1984;140421- 424
PubMed
Prockop  LD Hyperglycemia: effect on the nervous system. Handbook of Clinical Neurology 1976;2779- 98
Maccario  M Neurological dysfunction associated with nonketotic hyperglycemia. Arch Neurol 1968;19525- 534
PubMed Link to Article
Freedman  KAPolepalle  S Transient homonymous hemianopia and positive visual phenomena in nonketotic hyperglycemic patients. Am J Ophthalmol 2004;1371122- 1124
PubMed Link to Article
Harden  CLRosenbaum  DHDaras  M Hyperglycemia presenting with occipital seizures. Epilepsia 1991;32215- 220
PubMed Link to Article
Johnson  SFLoge  RV Palinopsia due to nonketotic hyperglycemia. West J Med 1988;148331- 332
PubMed

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