Ophthalmologists should be aware of advances in the management of orbital mucormycosis, so that medical and surgical interventions are appropriately used in treating the disease. We were able to effectively treat a case of rhino-orbital mucormycosis associated with a cavernous sinus and internal carotid artery thrombosis with surgery and the administration of posaconazole, amphotericin B, interferon gamma, and heparin. Because most patients show clinical improvement with surgical debulking and amphotericin B therapy, we cannot precisely determine the efficacy of posaconazole in the setting of the concurrent treatment modalities. Interferon gamma, a proinflammatory cytokine, up-regulates the immune system against fungi by activating polymorphonuclear leukocytes, monocytes, and macrophages. Interferon gamma has been used as adjunctive therapy to treat fungal infections in other immunocompromised disease states, and anticoagulation is believed to be important in preventing secondary sequelae such as stroke.5,6 Future in vivo studies may better elucidate the clinical efficacy of the azole class of antifungals in the therapy of invasive Zygomycetes infections.