Dissected orbital contents from 2 mummies discovered in the Atacama Desert were acquired from the University of Minnesota, Duluth. Conventional carbon dating techniques were used. The first specimen was from a 2-year-old boy dating back to 1000 AD, and the second specimen came from a 23-year-old woman whose remains dated back to 1250 AD. We received approval from the University of California, Davis, Human Anatomical Specimen Authorization Committee, to conduct the study. Examination of the desiccated tissue disclosed fragile tan- brown fragments of lightweight tissue without recognizable physical anatomical landmarks. Using an empirically modified formula based on the previously described Sandison technique,4 the mummified specimens were successfully rehydrated using a solution composed of 3 parts 96% ethanol, 5 parts 1% aqueous formalin, and 2 parts 5% aqueous sodium carbonate. The specimens were immersed for 24 hours. Visual inspection of the rehydrated specimens confirmed that the tissue represented orbital contents. Gross findings included extraocular muscle, orbital bone, and hair-bearing periorbital skin (Figure 1). Deep inside the orbit, the flattened globe was collapsed on itself and adhered to the roof of the orbit. Once rehydrated, mummified tissue must be chemically preserved or it will quickly disintegrate. Rehydrated tissues were preserved in 4% buffered formalin. After 24 hours of formalin fixation, the specimens were manually sectioned and chemically preserved before representative portions were embedded into paraffin blocks. Microtome sections averaging 5 μm thick were floated in a water bath, mounted on glass slides, dried, and subsequently stained with either hematoxylin-eosin or periodic acid–Schiff. Cover glasses were applied, and the stained slides were then examined by light microscopy.