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Photo Essay |

Revisiting Talc Retinopathy

Christopher I. Zoumalan, MD; Michael F. Marmor, MD
Arch Ophthalmol. 2007;125(7):988. doi:10.1001/archopht.125.7.988.
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Talc retinopathy is a well-established ocular finding in long-term intravenous drug users. Talc is a filler in oral medications such as methylphenidate as well as narcotics such as heroin, and talc retinopathy is commonly described in textbooks as an embolic phenomenon affecting the retinal arteries and capillaries.1,2 This is technically correct, but it is sometimes forgotten that only very small particles can clear the pulmonary capillaries to reach the ocular circulation. While circulating talc particles might occlude some small capillaries, particles that are large enough to be visible ophthalmoscopically represent an accumulation of microemboli in vessel walls. Our case provides an unusually graphic demonstration that the particles seen clinically are not single emboli.

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A, Multiple intravascular talc particles throughout retinal arteries, capillaries, and veins (arrows). B, Talc deposits at venous junctions (yellow arrows) and in a venular trunk (blue arrow).

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