On March 31, 2005, 2 areas of full-thickness corneal perforation at the nasal and temporal CK-treated spots with iris plugging had developed. Treatment with oral acetazolamide and ascorbic acid, as well as 1% atropine sulfate, was given and the eye was patched. On April 4, 2005, the patient was taken to the operating room and the temporal iris plug was freed; the nasal iris plug was not removed to enable vascularization of the cornea. Glue was applied and a bandage contact lens placed. Serologic testing results revealed that the patient was positive for antinuclear antibody (1:320; positive, >160) and had antibodies to SS-A and SS-B (immune status ratio, 4.6 and 4.7, respectively; positive, >1.2). The diagnosis of Sjögren syndrome was made; the patient was treated systemically with celecoxib and prednisone.