Cancer-associated retinopathy is most commonly associated with small cell carcinoma of the lung. Cases have also been reported in patients with breast, cervical, uterine, and endometrial carcinoma. An autoimmune mechanism against retinal antigens, including recoverin and enolase, has been proposed. Antibodies against recoverin (a calcium-binding protein found in retinal photoreceptor cells) may activate cell apoptotis via a calcium-dependent pathway lead-ing to retinal degeneration with loss of photoreceptor outer segments and outer nuclear layers seen on histopathology.4 Cancer-associated retinopathy with antirecoverin antibodies is associated with severe, progressive visual loss and profound abnormalities seen on electroretinography. Various treatments, including systemic steroids, plasmapheresis, and calcium channel blockers, have been tried with little success.