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Letters |

Glial Cell Proliferation Under the Internal Limiting Membrane in a Patient With Cellophane Maculopathy

Christos Haritoglou, MD; Ricarda G. Schumann, MD; Anselm Kampik, MD; Arnd Gandorfer, MD
Arch Ophthalmol. 2007;125(9):1301-1302. doi:10.1001/archopht.125.9.1301-b.
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Histological studies1,2 on epiretinal membranes have described cellular proliferations including hyalocytes, retinal glial cells, and retinal pigment epithelial cells on and confined to the vitreal surface of the internal limiting membrane (ILM). We report a case of cellular proliferation at the retinal surface of the ILM—in other words, under the ILM—in a patient with cellophane maculopathy.

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Figure 1.

A preoperative optical coherence tomographic scan through the macular area (A) and an intraoperative photograph of the fundus (B).

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Figure 2.

Transmission electron photomicrographs show cellular components strictly located at the retinal side (arrow) of the internal limiting membrane (ILM) (asterisk) with the vitreal side (arrowhead) being devoid of cellular proliferation (original magnification ×4800) (A); glial cells (arrow) characterized by massive accumulation of intracytoplasmatic intermediate filaments (IF) (asterisk indicates ILM; original magnification ×9500) (B); glial cells appearing as a multilayered membrane under the ILM (asterisk) (original magnification ×9500) (C); glial cells filled in ILM (asterisk) folds (original magnification ×2400) (D); a continuous layer of native vitreous collagen (arrowhead) at the vitreal side of the ILM (asterisk) but no cellular components (original magnification ×4800) (E); and native vitreous collagen fibrils (arrowheads) regularly arranged and characterized by a fibril diameter of 10 to 16 nm (higher magnification of E) (original magnification ×11 500) (F).

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