A 68-year-old woman was diagnosed with primary open-angle glaucoma in September 2002. Topical latanoprost was commenced in both eyes, with a good control of intraocular pressure. In April 2005, a malignant melanoma was surgically excised from the left side of the patient's face and skin was grafted to this area from her neck behind the ear. Histology confirmed a low-risk, superficial, spreading malignant melanoma in situ, which was excised with adequate margins. In September 2005, severe darkening of the skin graft was noted together with subtle bilateral periocular hyperpigmentation and eyelid-margin hyperemia (Figure 1). Her medication was switched from latanoprost to topical brinzolamide in both eyes with a good control of the intraocular pressure. One month after stopping latanoprost, the skin graft had lightened significantly and the subtle bilateral periocular hyperpigmentation and eyelid-margin hyperemia had resolved (Figure 2).