We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editorial |

Is Neuromyelitis Optica Eyeing a Distinct Path From Multiple Sclerosis?

Christopher C. Glisson, DO; Steven L. Galetta, MD
Arch Ophthalmol. 2008;126(1):128-129. doi:10.1001/archophthalmol.2007.3.
Text Size: A A A
Published online


Devic1 originally defined neuromyelitis optica (NMO) in the late 19th century as an acute monophasic syndrome characterized by bilateral (or rapidly sequential) optic neuritis and severe myelitis; attacks were limited to the optic nerve and spinal cord and resulted in significant disability. Subsequently, variations in clinical presentation, frequency of relapses, and degree of severity have been reported.27 Since 1999, 2 versions of standardized clinical criteria for the diagnosis of NMO have been suggested,8,9 and further revisions are likely in the near future. Given the lack of precisely defined clinical and diagnostic features, controversy has emerged regarding the potential relationship of NMO with other inflammatory conditions of the central nervous system, most notably multiple sclerosis (MS). The need to clearly distinguish between these conditions at the time of diagnosis, however, may be critical, given the perceived deleterious effect of NMO on neurologic function and the differences in treatment strategies aimed at limiting catastrophic consequences, such as bilateral vision loss and impaired motor function.6,10

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

1 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles