A 65-year-old man was initially seen with vision loss in his left pseudophakic eye for 2 days, with visual acuity limited to hand motions. Fundus examination revealed a superior bullous macula–off retinal detachment with 4 retinal horseshoe tears at the 9-, 10-, 1-, and 3-o’clock positions, as well as a large long tear at the 11-o’clock position associated with grade A proliferative vitreoretinopathy. The patient underwent standard 20-gauge 3-port pars plana vitrectomy (Accurus; Alcon Laboratories, Inc, Fort Worth, Texas) with PFCL injection (DKline; Bausch & Lomb, Montpellier, France), laser treatment to the retinal tears, and PFCL-air exchange, followed by isovolumetric perfluoroethane tamponade. One month later, his visual acuity was 20/800 OS. The vitreous cavity was 25% filled with gas and the retina reattached, but 2 small PFCL bubbles were noticed beneath the macula (Figure, A). The presence of subfoveal PFCL was confirmed by optical coherence tomography (OCT) (Figure, B). Removal of all traces of subfoveal PFCL was performed 2 weeks later through a 3-port pars plana route. Retinal detachment of the posterior pole was induced by slowly injecting saline solution through a retinal puncture near the inferotemporal vessels using a 39-gauge flexible cannula (Synergetics, Inc, O’Fallon, Missouri). The cannula was placed on a 10-mL syringe filled with balanced salt solution and connected to the injection line of the vitrectomy machine at an injection pressure of 4 mm Hg. The serous retinal detachment was slowly enlarged to the middle inferior periphery. Balanced salt solution (0.8 mL) was finally injected subretinally. Fluid-air exchange with 1 mL of filtered air was performed after closure of the sclerotomies. The patient was instructed to keep an upright head positioning during the immediate postoperative period to force the subretinal PFCL toward the inferior peripheral area. One day after surgery, the retina was attached, and the macula was free of PFCL, with a normal recovery profile on OCT (Figure, C and D). The subretinal PFCL droplet was displaced inferiorly at the 6-o’clock position. At 6 months after surgery, the macula was unchanged (Figure, E), and visual acuity had improved to 20/32 OS.