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Is a History of Diabetes Mellitus Protective Against Developing Primary Open-angle Glaucoma?

Mae O. Gordon, PhD; Julia A. Beiser; Michael A. Kass, MD ; Ocular Hypertension Treatment Study Group
Arch Ophthalmol. 2008;126(2):280-281. doi:10.1001/archophthalmol.2007.35.
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In 2002, the Ocular Hypertension Treatment Study1 (OHTS) reported baseline factors that increased the risk for developing primary open-angle glaucoma (POAG): older age, a larger vertical cup-disc ratio, higher intraocular pressure, greater Humphrey visual field pattern standard deviation, and a thinner central corneal measurement. A history of diabetes mellitus at baseline appeared to be protective against developing POAG. Six of the 191 participants (3.1%) who reported diabetes mellitus at baseline developed POAG compared with 119 of the 1427 participants (8.3%) who did not (multivariate hazard ratio, 0.37; 95% confidence interval, 0.15-0.90). This finding was unexpected and contradicted most of the literature on risk factors for POAG.24


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