In August 1995, a 31-year-old woman experienced blurring of vision in her right eye that was accompanied by headache, rhinorrhea, and right eye pain. Over 2 days, visual acuity deteriorated to NLP and an MRI showed enhancement of the right optic nerve without brain abnormalities. She was treated with 1 week of IV methylprednisolone and her vision returned to normal within 1 month. She was well until June 1999, when she experienced the same symptoms. Visual acuities were 20/400 OD and 20/20 OS, and there was a relative afferent pupillary defect, a large central scotoma, and optic nerve pallor in the right eye. There were minimal patchy paracentral defects in the left eye. An MRI revealed right prechiasmal optic nerve enhancement, as well as mild enhancement of the left optic nerve. A new T2-weighted hyperintense lesion was seen in the body of the corpus callosum. A course of IV methylprednisolone was given, but vision did not improve. Findings from neurological examination in November were normal except for hyperreflexia of the left biceps and brachioradialis. Results from a cervical spine MRI were normal and reflexes were symmetric in February 2000. A lumbar puncture showed normal contents, including negative oligoclonal bands and IgG. Erythrocyte sedimentation rate, angiotension-converting enzyme, and serum protein electrophoresis values were normal. During a pregnancy in 2001, she experienced fleeting bilateral hand numbness when fatigued, but her neurological examination findings were normal. In July 2004, she began to experience 1- to 2-minute episodes of pain across her pelvis and thighs without bowel or bladder symptoms. Apart from 4+/5 right psoas strength, findings from her neurological examination were normal. A cervicothoracic MRI with contrast showed no abnormalities and the sensory episodes subsided within several months and her strength normalized.