The Archives will be publishing a special theme issue on translational research. The issue will include (1) reviews of successes and failures in translating laboratory research into clinical applications; (2) descriptions of new experimental models as test beds for novel therapies; (3) discussion of end points for clinical trials, including surrogate measures; (4) examples of new preclinical research with a high likelihood of translation into clinical studies. The issue will include a combination of invited papers and papers presenting original research. Leonard A. Levin, MD, PhD, will be editor for this special issue. We invite and encourage all investigators to submit manuscripts describing original research and reviews by September 1, 2008. All manuscripts submitted for this issue are subject to an expedited peer review. Early receipt ensures the best chance for acceptance for this special issue. Accepted manuscripts not included in this issue will be published in other issues of the Archives. Please note in the cover letter that the submission is for the “Translational Research” theme issue. The expected publication date for this issue is April 2009.