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Research Letters |

Dacryoadenitis and Orbital Myositis Associated With Lyme Disease FREE

Juan C. Nieto, MD; Nancy Kim, MD, PhD; Mark J. Lucarelli, MD
Arch Ophthalmol. 2008;126(8):1165-1166. doi:10.1001/archopht.126.8.1165.
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To our knowledge, Lyme disease–associated orbital myositis has been serologically confirmed in 3 reported cases.13 No cases of dacryoadenitis have been reported in association with this disease entity.

A 66-year-old, previously healthy woman had a 6-day history of right periorbital edema, erythema, diplopia, pain with eye movement, tearing, nausea, and vomiting. She reported a deer tick bite on the posterior neck 2 months prior that occurred while hunting during the early summer months in northern Wisconsin. The bite was followed by 3 weeks of fever, nausea, diarrhea, weakness, arthralgias, and a diffuse rash, all of which resolved after a 10-day course of ciprofloxacin hydrochloride.

Examination revealed best-corrected visual acuities of 20/20 OD and 20/25 OS as well as no afferent pupillary defect. Intraocular pressure measured 15 mm Hg OU. There was a mild right exotropia with moderately limited right eye ductions in all fields of gaze. Binocular diplopia was reported 10° to 15° away from primary in all directions.

Moderate right periorbital edema, erythema, and upper eyelid ptosis were present (Figure 1). Mild right-sided proptosis was noted on Hertel exophthalmometry with measurements of 18 mm OD and 16 mm OS. Slitlamp examination revealed mild chemosis and injection of the right conjunctiva, but the results were otherwise unremarkable. Dilated funduscopy was normal bilaterally with no evidence of optic disc edema, subretinal fluid, or posterior segment inflammation.

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Figure 1.

Periorbital edema and erythema (A) as well as ptosis (B) in a woman with serologically confirmed Lyme disease–associated orbital inflammation.

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A noncontrast head computed tomographic scan revealed subtle lateral and medial rectus muscle and tendon enlargement with mild proptosis (Figure 2A). Orbital magnetic resonance imaging with gadolinium, obtained 4 days after the computed tomographic scan, revealed mild inflammatory changes within the right preseptal region with postseptal enlargement of the right lacrimal gland as well as right lateral and medial recti with tendon involvement (Figure 2B).

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Figure 2.

Images from a patient with Lyme disease–associated orbital inflammation. A, A computed tomographic scan without contrast demonstrates mild right-sided proptosis and right lateral and medial recti enlargement involving the tendon insertions. B, A T2-weighted magnetic resonance image with contrast reveals mild right-sided proptosis, mild enlargement of the right lacrimal gland, and enlarged right lateral and medial recti with tendon involvement.

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Given the paucity of clinical or imaging evidence of infectious orbital cellulitis, the patient began receiving oral prednisone (60 mg daily) for presumed orbital inflammation. She improved within 1 week of therapy. However, with a decrease to 50-mg daily therapy, her symptoms worsened until her dose was increased back to 60 mg daily.

Laboratory data revealed an elevated erythrocyte sedimentation rate (108 mm/h), an elevated C-reactive protein level (60 mg/L [to convert to nanomoles per liter, multiply by 9.524]), and a positive Lyme enzyme immunoassay screen (Lyme index value, 3.65; positive result is > 1.21). The complete blood cell count results, thyroid-stimulating hormone level, antineutrophil cytoplasmic antibody level, and rheumatoid factor level were normal.

Based on the positive Lyme serological results, treatment with oral doxycycline (100 mg twice daily) was started for Lyme-associated orbital inflammation. The oral steroid was continued and tapered by 10 mg weekly. Within 2 weeks of starting doxycycline therapy, the patient's symptoms had largely resolved. She completed a 4-week course of doxycycline and an 8-week tapered course of prednisone with complete resolution of her symptoms.

Medline indexes only 3 cases of serologically confirmed Lyme-associated orbital myositis.13 Other reported cases have lacked serological confirmation.4,5 Additionally, a Medline search and a review of several major textbooks revealed no reported cases of dacryoadenitis secondary to Borrelia burgdorferi infection.

Direct spirochete muscle infiltration has been demonstrated in extraorbital muscle sites in Lyme myositis.6 This is likely the process leading to orbital myositis. However, to date, no direct evidence of spirochetes in orbital muscle exists because biopsy in orbital myositis is not commonly performed. In atypical cases of orbital inflammation with history or features suggestive of Lyme disease, biopsy might be indicated. Additionally, the likely presence of spirochetes in the muscle warrants antibiotic treatment. The role of steroid therapy is unclear, although such treatment might abate the inflammatory response as the B burgdorferi organisms are eradicated.

The mechanism for lacrimal gland inflammation apparent in our patient was unclear, and tissue biopsy would have been required to differentiate between direct infiltration and sterile inflammation.

Correspondence: Dr Nieto, Oculoplastics Service, Department of Ophthalmology and Visual Sciences, University of Wisconsin Hospital and Clinics, 2870 University Ave, Ste 102, Madison, WI 53705 (jnieto@uwhealth.org).

Financial Disclosure: None reported.

Carvounis  PEMehta  APGeist  CE Orbital myositis associated with Borrelia burgdorferi (Lyme disease) infection. Ophthalmology 2004;111 (5) 1023- 1028
PubMed Link to Article
Pendse  SBilyk  JRLee  MS The ticking time bomb. Surv Ophthalmol 2006;51 (3) 274- 279
PubMed Link to Article
Holak  HHolak  NHuzarska  MHolak  S Tick inoculation in an eyelid region: report of five cases with one complication of the orbital myositis associated with Lyme borreliosis. Klin Oczna 2006;108 (4-6) 220- 224
PubMed
Seidenberg  KBLeib  ML Orbital myositis with Lyme disease. Am J Ophthalmol 1990;109 (1) 13- 16
PubMed
Fatterpekar  GMGottesman  RISacher  MSom  PM Orbital Lyme disease: MR imaging before and after treatment: case report. AJNR Am J Neuroradiol 2002;23 (4) 657- 659
PubMed
Müller-Felber  WReimers  CDde Koning  JFischer  PPilz  APongratz  DE Myositis in Lyme borreliosis: an immunohistochemical study of seven patients. J Neurol Sci 1993;118 (2) 207- 212
PubMed Link to Article

Figures

Place holder to copy figure label and caption
Figure 1.

Periorbital edema and erythema (A) as well as ptosis (B) in a woman with serologically confirmed Lyme disease–associated orbital inflammation.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Images from a patient with Lyme disease–associated orbital inflammation. A, A computed tomographic scan without contrast demonstrates mild right-sided proptosis and right lateral and medial recti enlargement involving the tendon insertions. B, A T2-weighted magnetic resonance image with contrast reveals mild right-sided proptosis, mild enlargement of the right lacrimal gland, and enlarged right lateral and medial recti with tendon involvement.

Graphic Jump Location

Tables

References

Carvounis  PEMehta  APGeist  CE Orbital myositis associated with Borrelia burgdorferi (Lyme disease) infection. Ophthalmology 2004;111 (5) 1023- 1028
PubMed Link to Article
Pendse  SBilyk  JRLee  MS The ticking time bomb. Surv Ophthalmol 2006;51 (3) 274- 279
PubMed Link to Article
Holak  HHolak  NHuzarska  MHolak  S Tick inoculation in an eyelid region: report of five cases with one complication of the orbital myositis associated with Lyme borreliosis. Klin Oczna 2006;108 (4-6) 220- 224
PubMed
Seidenberg  KBLeib  ML Orbital myositis with Lyme disease. Am J Ophthalmol 1990;109 (1) 13- 16
PubMed
Fatterpekar  GMGottesman  RISacher  MSom  PM Orbital Lyme disease: MR imaging before and after treatment: case report. AJNR Am J Neuroradiol 2002;23 (4) 657- 659
PubMed
Müller-Felber  WReimers  CDde Koning  JFischer  PPilz  APongratz  DE Myositis in Lyme borreliosis: an immunohistochemical study of seven patients. J Neurol Sci 1993;118 (2) 207- 212
PubMed Link to Article

Correspondence

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