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Multimodal Fundus Imaging in Foveal Hypoplasia: Combined Scanning Laser Ophthalmoscope Imaging and Spectral-Domain Optical Coherence Tomography FREE

Peter Charbel Issa, MD; Michael Foerl, MD; Hans-Martin Helb, MD; Hendrik P. N. Scholl, MD, MA; Frank G. Holz, MD
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Section Editor: W. Richard Green, MD

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Arch Ophthalmol. 2008;126(10):1463-1465. doi:10.1001/archopht.126.10.1463.
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Foveal hypoplasia is a rare disease that mostly occurs in association with other systemic or ocular diseases, such as albinism or aniridia. Diagnosis can be challenging, especially if foveal hypoplasia is an isolated finding. In recent years, optical coherence tomography (OCT) has been described as a useful tool to confirm the suspected diagnosis.13However, the common asso ciation of nystagmus with foveal hypoplasia may generate artifacts in OCT scans and may lead to off-center scans and therefore unreliable results.1We examined 2 patients with foveal hypoplasia by using a simultaneous imaging device that combines a confocal scanning laser ophthalmoscope with a spectral domain OCT (Spectralis HRA+OCT; Heidelberg Engineering, Heidelberg, Germany). An integrated eye-tracking system ensures that the high-resolution OCT images are obtained at the exact retinal location that is selected on the stabilized fundus image. The principles of the Declaration of Helsinki were followed.

Case 1

A 54-year-old woman had long-standing impaired visual acuity and mild photophobia. Best-corrected visual acuity was 20/32 OU. There was no nystagmus. A minor hyperopic astigmatism was present in her right eye (+1.0 diopter sphere/−0.75 cylinder × 30°) and a myopic astigmatism in her left eye (−0.5 diopter sphere/−0.75 cylinder × 125°). Color vision was normal on examination with Ishihara plates and panel D-15 testing, as was the anterior segment, aside from a faint posterior subcapsular cataract secondary to long-standing steroid therapy for Crohn disease. The iris was gray with small patches of pigmentation on the anterior stroma and did not transilluminate. The fundus had a normal pigmentation, the macula showed slightly mottled pigment irregularities, and there was no foveolar or macular reflex on funduscopy.

Case 2

An otherwise healthy 9-year-old boy was referred for unexplained bilateral low visual acuity that had been unchanged for years. Visual acuity was 20/63 OD and 20/50 OS, and a slow rotating nystagmus was present. The anterior segment of the eye revealed a posterior embryotoxon. The gray iris showed patches of pigmentation and was without transillumination. A deep anterior chamber, despite hyperopia of +6 diopters, was caused by a large radius of the cornea as assessed by corneal topography. Funduscopically, there was no foveolar reflex and no oval macular reflex. The peripheral fundus showed an overall light pigmentation with visible large choroidal vessels.

Retinal vessels at the posterior pole extended close to the presumed foveal area in both patients and were tortuous in patient 2. Some small vessels crossed the horizontal meridian. Fundus autofluorescence imaging did not show the typical foveal darkening due to absorption of the excitation light by macular pigment (Figure, A). This finding was more pronounced in patient 2. Confocal blue reflectance imaging revealed a concentric wrinkling of the inner retinal surface surrounding the posterior pole in patient 2 (not shown).

Place holder to copy figure label and caption
Figure.

Two eyes of patients with foveal hypoplasia and a healthy eye. A, Fundus autofluorescence shows reduced (patient 1) or almost absent (patient 2) foveal attenuation of fundus autofluorescence by macular pigment. B, Topographic retinal thickness map. There is no foveal pit and no clivus or anticlivus in either patient with foveal hypoplasia. C, Near-infrared confocal reflectance images showing the location of the optical coherence tomographic scan (green line) in D. The white dot in the middle of the green line in patient 1 is an optical artifact. D, Single high-resolution optical coherence tomographic scans. All retinal layers continue through the presumed foveal area and no foveal contour is seen in the patients with foveal hypoplasia. There is thickening of the photoreceptor layer at the presumed foveal center in patient 1 but no similar finding in patient 2.

Graphic Jump Location

Three-dimensional OCT volume scans consisting of a narrow sequence of single horizontal scans detected neither a foveal pit nor a clivus or anticlivus at the central retina (Figure, B) (video of a volume scan through the central retina of the right eye in patient 1 is available here). Single scans through the presumed foveal area showed continuity of all neurosensory retinal layers (Figure, C). The retinal layer representing the photoreceptors was broader at the presumed foveal center compared with other retinal areas in patient 1.

In both cases, 3-dimensional imaging of the central retina confirmed the suspected diagnosis of foveal hypoplasia. Moreover, high-resolution OCT allowed a reliable diagnosis of subtle anatomic changes of the macula in spatial correlation with the confocal fundus image. The thickening of the photoreceptor layer found in patient 1 at the presumed foveal center is also present in healthy eyes. This thickening is thought to be due to the elongated cone photoreceptors at the central fovea4and may be a sign of lesser anatomic alterations in a subset of patients with foveal hypoplasia, as it was not present in patient 2, who had worse visual function than patient 1.

Analyzing fluorescein angiographs in patients with foveal hypoplasia, Oliver and coworkers5observed a similar fluorescence at the macular area compared with more peripheral parts of the fundus. They concluded that this phenomenon may be related to the amount of macular pigment present. This suggestion is supported by our finding that the usual foveal attenuation of fundus autofluorescence by macular pigment is reduced (patient 1) or almost absent (patient 2). Therefore, an intact foveal anatomy appears to be related to a physiological macular pigment storage in the neurosensory retina. Because this finding was more pronounced in patient 2, who had worse visual acuity, it may be speculated that macular pigment density correlates with the anatomical and functional integrity of the fovea in patients with foveal hypoplasia.

The integrated eye-tracking system that continuously compensates for eye movements during the examination allowed recordings in all imaging modes, even in patient 2, who had a slow rotating nystagmus. Therefore, even in the presence of a nystagmus, the system may be of diagnostic value in unexplained low visual acuity to rule out otherwise occult macular pathologies.

Correspondence:Dr Holz, Department of Ophthalmology, University of Bonn, Ernst-Abbe-Str 2, D-53127 Bonn, Germany (frank.holz@ukb.uni-bonn.de).

Financial Disclosure:The equipment used to conduct the study was provided by Heidelberg Engineering. Dr Holz has served as a consultant for Heidelberg Engineering.

Role of the Sponsor:The sponsor had no influence on the design or conduct of the study; the collection, management, analysis, or interpretation of the data; or the preparation, review, or approval of the manuscript.

Seo  JHYu  YSKim  JHChoung  HKHeo  JWKim  SJ Correlation of visual acuity with foveal hypoplasia grading by optical coherence tomography in albinism. Ophthalmology 2007;114 (8) 1547- 1551
PubMed Link to Article
Meyer  CHLapolice  DJFreedman  SF Foveal hypoplasia in oculocutaneous albinism demonstrated by optical coherence tomography. Am J Ophthalmol 2002;133 (3) 409- 410
PubMed Link to Article
Recchia  FMCarvalho-Recchia  CATrese  MT Optical coherence tomography in the diagnosis of foveal hypoplasia. Arch Ophthalmol 2002;120 (11) 1587- 1588
PubMed
Shahidi  MWang  ZZelkha  R Quantitative thickness measurement of retinal layers imaged by optical coherence tomography. Am J Ophthalmol 2005;139 (6) 1056- 1061
PubMed Link to Article
Oliver  MDDotan  SAChemke  JAbraham  FA Isolated foveal hypoplasia. Br J Ophthalmol 1987;71 (12) 926- 930
PubMed Link to Article

Figures

Place holder to copy figure label and caption
Figure.

Two eyes of patients with foveal hypoplasia and a healthy eye. A, Fundus autofluorescence shows reduced (patient 1) or almost absent (patient 2) foveal attenuation of fundus autofluorescence by macular pigment. B, Topographic retinal thickness map. There is no foveal pit and no clivus or anticlivus in either patient with foveal hypoplasia. C, Near-infrared confocal reflectance images showing the location of the optical coherence tomographic scan (green line) in D. The white dot in the middle of the green line in patient 1 is an optical artifact. D, Single high-resolution optical coherence tomographic scans. All retinal layers continue through the presumed foveal area and no foveal contour is seen in the patients with foveal hypoplasia. There is thickening of the photoreceptor layer at the presumed foveal center in patient 1 but no similar finding in patient 2.

Graphic Jump Location

Tables

References

Seo  JHYu  YSKim  JHChoung  HKHeo  JWKim  SJ Correlation of visual acuity with foveal hypoplasia grading by optical coherence tomography in albinism. Ophthalmology 2007;114 (8) 1547- 1551
PubMed Link to Article
Meyer  CHLapolice  DJFreedman  SF Foveal hypoplasia in oculocutaneous albinism demonstrated by optical coherence tomography. Am J Ophthalmol 2002;133 (3) 409- 410
PubMed Link to Article
Recchia  FMCarvalho-Recchia  CATrese  MT Optical coherence tomography in the diagnosis of foveal hypoplasia. Arch Ophthalmol 2002;120 (11) 1587- 1588
PubMed
Shahidi  MWang  ZZelkha  R Quantitative thickness measurement of retinal layers imaged by optical coherence tomography. Am J Ophthalmol 2005;139 (6) 1056- 1061
PubMed Link to Article
Oliver  MDDotan  SAChemke  JAbraham  FA Isolated foveal hypoplasia. Br J Ophthalmol 1987;71 (12) 926- 930
PubMed Link to Article

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