An 11-year-old girl was referred for new-onset blurry vision in the right eye 2 weeks after being vaccinated with the Oka strain of the varicella-zoster virus (Varivax; Merck and Co, Inc, Whitehouse Station, New Jersey). A standard dose of 0.5 mL was injected into the left deltoid without any resulting skin reaction. Her medical history was significant for mild eczema and a seizure disorder treated with daily oral levetiracetam, and results of an ocular examination 1 year prior were normal. One week following the administration of the vaccine, she developed rhinitis and a mild fever that lasted 2 days. Two weeks following the vaccination, she noted blurry vision and photophobia in the right eye and her mother noted 3 white spots on the cornea. On examination, visual acuity measured 20/30 OD and 20/20 OS. Corneal sensation was normal in both eyes. Intraocular pressure measured 14 mm Hg OD and 18 mm Hg OS. There was no conjunctival injection or anterior chamber inflammation. In the right cornea, there were several well-circumscribed avascular opacities that appeared to be white blood cells at varying stromal depths (Figure 1). The left eye was unaffected. The posterior segment examination results were normal in both eyes. Epstein-Barr virus DNA was not detected by polymerase chain reaction. The patient was treated with a 1-month course of prednisolone acetate, 1%, starting at 4 times per day, with resolution of the interstitial keratitis at 2 weeks and return of visual acuity to 20/20 OD (Figure 2). At the 6-month follow-up visit, there was no sign of recurrence.