Financial Disclosure: A complete list of all DRCR.net investigator financial disclosures can be found at http://www.drcr.net. Dr Aiello has received compensation for travel and honoraria from and/or has served on the speakers' bureau for Allergan Inc; has consulted for and received compensation for travel and honoraria from and/or has served on the speakers' bureau for Eli Lilly; has consulted for Novartis; has stock ownership or options in Opko Health; has consulted for and received compensation for travel from Pfizer; and has served on the data monitoring board of a Thrombogenics study. Dr Bressler's work has been supported by research grants from Carl Zeiss, Genentech, Novartis, Emmes, Acucela, Notal Vision, Regeneron, Fovea Pharmaceuticals, Schering-Plough, Merck, Pfizer, Allergan Inc, Othera, Jerini, Bausch & Lomb; his spouse has consulted for Notal Vision, Genentech, Oxigene, Potentia, and Astra Zeneca; his spouse has received compensation for travel from Genentech; and his spouse has received honoraria from Pfizer. Dr Ferris is one of the inventors of a patent entitled “Nutritional supplement to treat macular degeneration” (No. 6,660,297), which was issued on December 9, 2003 and is owned by Bausch & Lomb. Dr Ferris has assigned his interest in the patent to the US government and receives government compensation. Dr Hartnett has consulted for Ophthalmic Research Associates. Dr Ip has consulted for Bausch & Lomb, Sirion Therapeutics, Genentech, and QLT; and his work has been supported by grants from Bausch & Lomb, Allergan Inc, and Neovista. Dr Kim's work has been supported by research grants from (OSI) Eyetech, Allergan Inc, Genentech, and Novartis; and she has consulted for Heidelberg.