A 68-year-old man with MF, stage T4N3M1B0 by TNMB classification,3 complicated by inguinal lymphadenopathy and epiglottal involvement had worsening vision over 2 weeks. He had previously been treated with UV light therapy enhanced with psoralen, gemcitabine hydrochloride, interferon, methotrexate sodium, and liposomal doxorubicin hydrochloride. Visual acuity was 20/25 OD and hand motions OS. His skin was diffusely hyperemic and edematous with several tumors (Figure 1A). Dense, bilateral, lobular-appearing hypopyon with admixed blood was present in each eye. Both irides had prominent neovascularization with rugate appearances and dense posterior synechiae (Figure 1B and C). B-scan ultrasonography showed no significant vitreous opacification or retinochoroidal infiltration, and ultrasound biomicroscopy revealed bilaterally thickened iris roots.