Macroscopically, the sectioned globe disclosed a 5 mm-high, 12 mm-wide, gray-white mass with a prominent brownish cap and dark pigmented foci (melanin) on the tumor surface (Figure, E). Histopathological examination revealed a choroidal mixed-cell–type melanoma rupturing the Bruch membrane and showing intratumoral and supratumoral hemorrhages (Figure, F). Severe atrophic and degenerative changes were present in the overlying retina. At the tumor apex, the thinning had progressed to obliteration of the retina with absence of the internal limiting membrane. Within the supratumoral hemorrhage, melanoma cells could be found percolated through the attenuated retina and into the immediately adjacent vitreous (Figure, F, insert). Immunohistochemically, these intravitreal cells were positive for S-100, HMB-45, PNL2, melan-A, tyrosinase, and MITF, but negative for iron stain.