Pathological examination showed a solid posterior tumor tapering into the inner nuclear layer of the retina (Figure 2A). The residual retinal lesion had numerous fleurettes, consistent with retinoma5,6 (Figure 2B). Fleurette-rich regions were not reactive to Ki-67 and p53 antibodies, and mitotic figures were rare. At the edge of the gap in the tumor from which the necrotic vitreous seeds had emerged, small, round retinoblastoma cells with little cytoplasm and no fleurettes stained positive for Ki-67, indicating proliferation and p53. The vitreous contained necrotic cellular debris. The optic nerve, optic nerve head, subarachnoid space, and choroid were free of tumor.