First described as a fungal entity, R seeberi is now classified in its own class, Mesomycetozoea.1 It undergoes a life cycle from trophocyte to mature sporangium, which produces endospores that are the infective units. Spores are transmitted from contaminated water and dust1 through epithelial defects on mucosal surfaces. The patient's use of soft contact lenses while swimming likely produced epithelial defects for transmission. Infection causes formation of highly vascular polyps most commonly found in the nasal mucosa and the conjunctiva. Ocular involvement occurs in 15% of cases,2 mostly in the conjunctiva, but dacryocystitis and scleral melting3 have been reported. Involvement of other mucosal membranes, skin, and internal organs has been reported.2 The polyps are covered with white spherules representing the sporangia, described as resembling a strawberry. In this patient the follicular conjunctivitis developed after exposure to the bayou water, and the presence of these strawberry lesions differentiated his condition from other inflammatory conditions such as giant papillary conjunctivitis commonly seen in contact lens wearers. Histopathologically, there is a fibromyxomatous stroma containing trophocytes and sporangia in all stages of development. Treatment involves excision with cryotherapy, but recurrences are common and medical therapy such as with dapsone4 remains controversial. In this patient, the follicular conjunctivitis recurred despite cessation of contact lens wear, also differentiating this condition from other contact lens–related inflammation. Culturing specimens usually does not yield growth of this organism and histopathological analysis has been the mainstay of diagnosis. This report shows identification with histopathological analysis, transmission electron microscopy, and polymerase chain reaction analysis. Interestingly, sequence data of polymerase chain reaction from this organism showed this isolate to be more similar to R seeberi from a canine sample than that of other human isolates.5,6 This patient did not have any dogs at home. As such, these data suggest that the genus Rhinosporidium may possess isolates capable of infecting multiple host types.