A total of 536 patients were identified from January 1, 1994, to December 31, 2008, equating to 35.7 cases/year with an annual incidence of 7 per 1 million population. Mean (SD) age at the initial visit was 63.8 (13.7) years; 54.1% of the patients were male; and 50.4% of the lesions occurred in the right eye. All patients had unilateral pathological findings. The average wait from referral to the first review at the ophthalmic oncology clinic was 17 days. Among the patients, 42.1% had an initial visual acuity of 6/9 or better and 28.8% had an initial visual acuity of 6/60 or worse. The lesion diameter was less than 10 mm (small) for 50.4% of patients, 10 to 15 mm (medium) for 38.3%, and greater than 15 mm (large) for 11.3%. There were 630 interventions, including ruthenium plaque radiotherapy for 51.1%, proton beam radiotherapy for 26.4%, and enucleation for 18.3% (8.2% primary enucleation). Other interventions included cataract surgery, vitrectomy, and local resection. No treatment group was normally distributed (P < .005). There was no significant difference in the median Scottish Index of Multiple Deprivation scores between the main treatment groups (Kruskal-Wallis P = .91) (Figure).