A 56-year-old man was in good health until developing a febrile illness 6 days prior to his first visit, followed 3 days later by the onset of redness and photophobia in the right eye. He was evaluated for presumed uveitis and treated hourly with topical steroid eyedrops, but he was referred to the uveitis clinic owing to progressive worsening and posterior segment extension. On examination, his visual acuity was light perception OD and 20/40 OS. Examination of the right eye revealed eyelid edema, conjunctival congestion, and a 1-mm hypopyon with fibrinous exudates in the anterior chamber, with no view of the ocular fundus. Results from examination of the left eye were unremarkable. Intraocular pressure was 10 mm Hg OU. He underwent urgent pars plana vitrectomy with injection of intravitreous vancomycin hydrochloride and amikacin sulfate and also received intravenous vancomycin, clindamycin phosphate, and cefotaxime sodium. Vitreous, anterior chamber, and blood cultures grew GBS. A complete blood cell count showed pancytopenia with toxic granulation. Diagnostic inpatient workup including echocardiography revealed no focus of infection. Bone marrow biopsy revealed the diagnosis of precursor T-cell acute lymphoblastic leukemia (Figure). The patient continued to receive parenteral cefotaxime for bacteremia and had systemic chemotherapy initiated by the oncology service, with repeat intravitreous tap and injection of vancomycin 3 days later. Results from the repeat cultures were negative. His visual acuity remained light perception OD 10 days after surgery.