Enucleation and evisceration are the 2 possible surgical management options for a disfigured or a painful blind eye.1- 3 Evisceration is replacing enucleation as the favored surgical option because of its potential advantages such as superior cosmesis, better prosthesis motility, and fewer implant-related complications.1- 3 Evisceration, however, is absolutely contraindicated in suspected intraocular malignancy. Before the availability of modern imaging techniques, 10% of blind, painful eyes with opaque media were found to contain unsuspected malignant tumors on histopathologic examination.3,4 Although rare, pathologists continue to encounter clinically unsuspected intraocular tumors during histopathologic examination of eviscerated eyes. Several anecdotal studies of unsuspected tumors found after evisceration exist.4- 13 Although these articles include cases of carcinoma of the nonpigmented ciliary epithelium, adenocarcinoma of the retinal pigment epithelium, choroidal lymphoma, choroidal ganglioneuroma, spindle cell neoplasm, anaplastic tumor, and retinoblastoma, uveal melanoma predominates. Eagle et al13 recently described a series of 7 additional cases of unsuspected uveal melanoma diagnosed in eviscerated specimens and have emphasized the role of detailed a medical history, clinical evaluation, and appropriate imaging before performing evisceration in painful blind eyes with opaque media. Our series comprises 6 cases of unsuspected intraocular tumors diagnosed following evisceration and elaborates on the lessons learned from this experience.