Postoperatively, the patient was treated with voriconazole, 200 mg orally twice daily, gatifloxacin, 0.3%, eyedrops 4 times daily, and prednisolone acetate, 1%, eyedrops 4 times daily. Six days after surgery, recurrence of the fungal infection in the host at the wound edge was noted. Tap and injection with voriconazole were performed and continued daily. Amphotericin B, 0.1 mL (100 μg/mL), was injected on the third day, and hourly amphotericin B, 0.15%, eyedrops were added owing to continued progression of the infiltrate. Five days later, the patient underwent a limbus-to-limbus penetrating keratoplasty because of worsening infection. Intraoperatively, the areas of the host cornea that clinically appeared to be infiltrated (superiorly from the 9-o’clock to 3-o’clock positions) were treated with double freeze-thaw cryotherapy before the cornea was excised, and the anterior chamber was irrigated with amphotericin B (100 μg/mL) and voriconazole (1 mg/mL).