Diabetes-related changes in the function and structure of the retinal pigment epithelium, Bruch membrane, and the choroidal circulation have been hypothesized to increase the risk of AMD.12,15 Histopathologic studies in eyes of diabetic patients have shown thickening of the basement membrane of the choriocapillaris walls, luminal narrowing, dropout of the choriocapillaris, and thickening of the Bruch membrane, which has been attributed to hyperglycemia.22,23 Studies of subfoveal choroidal blood flow have found that it is reduced in patients with both nonproliferative and proliferative diabetic retinopathy.24,25 Few studies have evaluated the limited epidemiologic evidence supporting the association between AMD and diabetes mellitus. The Blue Mountains Eye Study12 reported that diabetes mellitus was significantly associated with the prevalence of geographic atrophy (OR, 4.0; 95% CI, 1.6-10.3). In the Age-Related Eye Disease Study,13 participants with unilateral neovascular AMD and a history of diabetes mellitus had a higher association with incident bilateral neovascular AMD than those without diabetes mellitus (OR, 1.88; 95% CI, 1.07-3.31). The Barbados Eye Study,14 found that, after adjusting for age, there was a 2.7-fold association between a history of diabetes mellitus and incident late AMD. In the cross-sectional population-based EUREYE study,15 a positive association between self-reported diabetes mellitus and neovascular AMD was found (OR, 1.81; 95% CI, 1.10-2.98). In the Women's Health Initiative Sight Exam Study, a history of diabetes was found to be associated with late AMD.26 However, as mentioned, to our knowledge, there has been no documented association in these studies or any other study between early AMD and diabetes mellitus. In this study, we found a significant association between early AMD and diabetes mellitus after adjusting for age, sex, current smoking, obesity, and hypertension.