Phenotypes are described mainly based on the physical appearance and site of occurrence of the opacity. Phenotypic variabilities among and within families have been documented, including nuclear, anterior polar, posterior polar, coralliform, cerulean (blue-dot), pulverulent, cortical, zonular, and sutural cataracts.1 Of the already characterized phenotypes, nuclear congenital cataracts are the most common type of hereditary congenital cataract.4 Despite attempts to categorize hereditary cataracts clinically, correlation of phenotypes with genetic locus and specific mutation is limited. The clinical and genetic heterogeneity of congenital cataracts is well substantiated. Conversely, congenital cataracts with similar or identical clinical phenotypes can result from mutations in completely different genes. Several genes have been associated with nuclear cataract to date (CRYAA, CRYBB1, CRYBB2, CRYBA3, CRYGC, CRYGD, GJA8, and GJA3).3 Therefore, it is appropriate to consider these genes as the top list of functional candidates in hereditary congenital cataracts. In this study, we screened 20 Chinese families with nuclear ADCC for mutations in 8 crystallin and 2 connexin genes.