Actinomyces can be a rare cause of infectious crystalline keratopathy, especially in an immune-suppressed condition such as a corneal graft. Infectious crystalline keratopathy is a unique corneal infection characterized by the slowly progressive development of needlelike opacities in the corneal stroma, most commonly caused by streptococcal species.1,2 To our knowledge, this is the first case of infectious crystalline keratopathy due to an organism with morphologic characteristics consistent with Actinomyces. There have been other rare reports of Actinomyces corneal infections. Severe corneal ulceration from Actinomyces has been reported,3 as has delayed-onset keratitis after laser in situ keratomileusis.4 In both of these cases, cure was achieved with debridement of the infected cornea and intensive treatment with topical antibiotics, as well as oral penicillin in the case of the corneal ulcer. Actinomyces has also been associated with chronic postoperative endophthalmitis that required surgical treatment.5Actinomyces species are more commonly encountered in ophthalmology as a cause of canaliculitis.6 In these cases, Actinomyces is difficult to eradicate medically and usually requires surgical treatment.