This was a retrospective record review of all patients undergoing Collaborative Ocular Melanoma Study–style brachytherapy at the Eye Institute of the Medical College of Wisconsin between January 1, 1996, and December 31, 2007. Institutional review board approval was obtained. Patients were identified by billing record search. Exclusion criteria included being younger than 18 years, having nonmelanotic tumors, and having incomplete medical documentation. The following data were gathered: preoperative IOP, age, sex, history of DM or glaucoma, tumor location and height, radiation dose, plaque diameter, daily IOP during brachytherapy, muscle disinsertion, and use of topical antiglaucoma medications.