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Research Letters |

Commercial Air Travel With a Small Intravitreous Gas Bubble FREE

Adam K. Muzychuk, MD; Feisal A. Adatia, MD; Bryce A. Ford, MD; Amin M. Kherani, MD
[+] Author Affiliations

Author Affiliations: Division of Ophthalmology, Department of Surgery (Dr Muzychuk) and Department of Ophthalmology (Drs Ford and Kherani), University of Calgary, and Calgary Retina Consultants (Drs Adatia and Kherani), Calgary, Alberta, Canada.


Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.144.
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Published online

Although the risks of air travel with an intravitreous gas bubble have been well documented, there have been suggestions in the literature that such a flight may be safe under certain conditions, especially with small bubbles. We report a case of significant visual field loss following commercial air travel in a patient with a 10% intravitreous perfluoropropane gas fill.

A 64-year-old man with a history of retinal detachment in the left eye visited his ophthalmologist with a 24-hour history of an “explosion” of floaters in the right eye. His history was also remarkable for glaucoma, for which he was receiving 2 medications but had no glaucomatous damage evident in the right eye on optical coherence tomography and visual field testing (Figure 1A and Figure 2A).

Place holder to copy figure label and caption
Figure 1.

The most recent preflight Goldmann visual field (A) compared with the postflight Goldmann visual field demonstrating a new superonasal defect (B). Colors have been uniformly altered to black and white. RNFLT indicates retinal nerve fiber layer thickness; S, superior; N, nasal; I, inferior; and T, temporal.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

The most recent preflight optical coherence tomographic scan (A) compared with the postflight scan demonstrating significant loss of nerve fiber layer tissue (B). Colors have been uniformly altered to black and white.

Graphic Jump Location

On dilated fundus examination, a large superotemporal retinal tear was found in the right eye. The patient was referred emergently to the on-call retinal specialist. The tear progressed to a superotemporal macula-on detachment despite laser retinopexy, and the patient underwent vitrectomy and gas-fluid exchange with 10% perfluoropropane. Treatment with oral acetazolamide was started as the intraocular pressure was found to be 27 mm Hg OD 1 day postoperatively; the intraocular pressure remained within normal limits thereafter.

On a postoperative visit exactly 1 month later, the patient's cup-disc ratio was recorded as a stable 0.3 and treatment with acetazolamide was discontinued. The gas bubble was noted to be well above the pupil on examination in the sitting position and was approximately one-third of the height from the ora serrata to the equator, thus indicating less than a 10% fill remaining. The risks of air travel with an intraocular gas bubble were explained, but the patient declined to have the gas removed before his planned flight the following week.

Soon after takeoff on a commercial aircraft, the patient noted moderate discomfort in the right eye followed by a complete loss of vision in this eye. The discomfort and loss of vision did not subside until shortly after landing. He did not experience similar symptoms 2 weeks later on the return flight.

On examination immediately following his return to Canada, the cup-disc ratio of his right optic nerve had increased from 0.3 to 0.5. His optical coherence tomographic scan demonstrated a striking loss of the nerve fiber layer from an average thickness of 96.99 μm before the flight to 85.55 μm afterward (Figure 1B). This change was accompanied by a corresponding new superonasal visual field defect demonstrated on Goldmann visual field examination (Figure 2B).

Vitreoretinal surgery often involves the use of air or medical gases, primarily perfluoropropane or sulfur hexafluoride, injected directly into the vitreous cavity. As resorption of these gases is first order, small gas volumes may be present for weeks or months.1 Although the risks of air travel with intraocular gas have been well documented, there have been some suggestions in the literature that under certain conditions (eg, low-altitude flight or small gas bubbles) flight with intraocular gas may be safe, if inadvisable.24

As an aircraft gains altitude, the atmospheric pressure decreases. Commercial flights routinely reach altitudes up to 40 000 feet above sea level, with cabin pressures typically maintained at less than 9000 feet. As the atmospheric pressure decreases, an intraocular gas bubble will undergo expansion following Boyle's law: P1V1 = P2V2, where P indicates the pressure of the system and V indicates the volume of the gas. The eye has several compensatory mechanisms including limited choroidal flattening, scleral expansion, and increased aqueous outflow, but these mechanisms are limited in their ability to accommodate expansion of the intraocular gas bubble.5 Once the globe's maximum capacity is reached, the intraocular pressure increases, which may result in acute glaucoma and even central retinal artery occlusion.6

Although the patient likely had diminished compensatory capacity for increasing intraocular pressures due to underlying glaucoma, we report this case as evidence that flight with even a small gas bubble is not without risk.

Correspondence: Dr Muzychuk, Rockyview Eye Clinic, 7007 14th St SW, Calgary, AB T2V 1P9, Canada (adam.muzychuk@med.ucalgary.ca).

Financial Disclosure: None reported.

Thompson  JT Kinetics of intraocular gases: disappearance of air, sulfur hexafluoride, and perfluoropropane after pars plana vitrectomy. Arch Ophthalmol 1989;107 (5) 687- 691
PubMed Link to Article
Dieckert  JPO’Connor  PSSchacklett  DE  et al.  Air travel and intraocular gas. Ophthalmology 1986;93 (5) 642- 645
PubMed Link to Article
Lincoff  HWeinberger  DStergiu  P Air travel with intraocular gas, II: clinical considerations. Arch Ophthalmol 1989;107 (6) 907- 910
PubMed Link to Article
Kokame  GTIng  MR Intraocular gas and low-altitude air flight. Retina 1994;14 (4) 356- 358
PubMed Link to Article
Lincoff  HWeinberger  DReppucci  VLincoff  A Air travel with intraocular gas, I: the mechanisms for compensation. Arch Ophthalmol 1989;107 (6) 902- 906
PubMed Link to Article
Mills  MDDevenyi  RGLam  WCBerger  ARBeijer  CDLam  SR An assessment of intraocular pressure rise in patients with gas-filled eyes during simulated air flight. Ophthalmology 2001;108 (1) 40- 44
PubMed Link to Article

Figures

Place holder to copy figure label and caption
Figure 1.

The most recent preflight Goldmann visual field (A) compared with the postflight Goldmann visual field demonstrating a new superonasal defect (B). Colors have been uniformly altered to black and white. RNFLT indicates retinal nerve fiber layer thickness; S, superior; N, nasal; I, inferior; and T, temporal.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

The most recent preflight optical coherence tomographic scan (A) compared with the postflight scan demonstrating significant loss of nerve fiber layer tissue (B). Colors have been uniformly altered to black and white.

Graphic Jump Location

Tables

References

Thompson  JT Kinetics of intraocular gases: disappearance of air, sulfur hexafluoride, and perfluoropropane after pars plana vitrectomy. Arch Ophthalmol 1989;107 (5) 687- 691
PubMed Link to Article
Dieckert  JPO’Connor  PSSchacklett  DE  et al.  Air travel and intraocular gas. Ophthalmology 1986;93 (5) 642- 645
PubMed Link to Article
Lincoff  HWeinberger  DStergiu  P Air travel with intraocular gas, II: clinical considerations. Arch Ophthalmol 1989;107 (6) 907- 910
PubMed Link to Article
Kokame  GTIng  MR Intraocular gas and low-altitude air flight. Retina 1994;14 (4) 356- 358
PubMed Link to Article
Lincoff  HWeinberger  DReppucci  VLincoff  A Air travel with intraocular gas, I: the mechanisms for compensation. Arch Ophthalmol 1989;107 (6) 902- 906
PubMed Link to Article
Mills  MDDevenyi  RGLam  WCBerger  ARBeijer  CDLam  SR An assessment of intraocular pressure rise in patients with gas-filled eyes during simulated air flight. Ophthalmology 2001;108 (1) 40- 44
PubMed Link to Article

Correspondence

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