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PATHOLOGIC CHANGES IN THE ORBIT IN PROGRESSIVE EXOPHTHALMOS:  WITH SPECIAL REFERENCE TO ALTERATIONS IN THE EXTRA-OCULAR MUSCLES AND THE OPTIC DISKS

HOWARD C. NAFFZIGER, M.D.
Arch Ophthalmol. 1933;9(1):1-2. doi:10.1001/archopht.1933.00830010004001.
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We have seen a number of patients suffering from progressive exophthalmos following thyroidectomy, in each of whom careful study revealed many findings of ophthalmologic interest.

For these patients a surgical treatment was devised which, in six instances, was highly satisfactory. In each, a similar mechanism for the exophthalmos was found, and the pathologic changes responsible for this disorder were proved.

The usual development of the condition is as follows: Thyroidectomy is performed on a patient with exophthalmic goiter who presents the usual elevated basal metabolic rate and cardiovascular and nervous manifestations. Clinical improvement follows, except that the exophthalmos does not disappear. In a variable period, often in three or four months, it becomes evident that the proptosis is increasing. As it proceeds an increased fulness of the lids is noted ; then lacrimation and epiphora appear. A watery appearance of the scleral conjunctiva is followed first by edema near

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