0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Effect of Elevated Intraocular Pressure on Blood Flow:  Occurrence in Cat Optic Nerve Head Studied With Iodoantipyrine I 125

Nunzio Sossi, PhD; Douglas R. Anderson, MD
Arch Ophthalmol. 1983;101(1):98-101. doi:10.1001/archopht.1983.01040010100018.
Text Size: A A A
Published online

• Iodoantipyrine was used to record relative blood flow in the retina, choroid, optic nerve head, lamina cribrosa, and postlaminar optic nerve of cats at different levels of intraocular pressure. The IOP could be elevated to within 25 mm Hg of mean femoral arterial pressure, with only a slight effect on blood flow in the retina, choroid, and optic nerve head. At higher IOPs, the blood flow is reduced in the retina, choroid, and optic nerve head, but, in the lamina cribrosa, the blood flow is reduced only with extreme pressure elevation and is not reduced at all in the intraorbital optic nerve. Thus, there is no demonstrated effect of IOP on blood flow preferentially in the normal optic nerve. It is concluded that there is an efficient autoregulation in the optic nerve head and lamina cribrosa so that the IOP over a wide range does not much influence blood flow under normal circumstances. These findings do not rule out a role of ischemia in the pathophysiology of glaucomatous cupping, which may be caused by faulty autoregulation.

Topics

Sign in to download this free article PDF

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in to download this free article PDF

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();