An Ocular Melanoma-Associated Antigen:  Molecular Characterization

Ming X. Wang, MD, PhD; James J. Earley Jr, MS; Jerry A. Shields, MD; Larry A. Donoso, MD, PhD
Arch Ophthalmol. 1992;110(3):399-404. doi:10.1001/archopht.1992.01080150097036.
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• Monoclonal antibody (MAb) 8-1H defines a highly conserved ocular melanoma-associated antigen. Based on a potential binding site of MAb8-1, we identified, molecularly cloned, and sequenced the gene, encoding this melanoma-associated antigen from a uveal melanoma copy DNA library. Nucleotide sequence analysis of the melanoma-associated antigen revealed characteristics of a membrane-bound protein of 238 amino acids (approximately 25 kd) with four transmembrane domains. The sequence of the ocular melanoma-associated antigen is identical to the sequence of a recently reported cutaneous melanomaassociated antigen, substantiating our previous studies regarding common antigens between ocular and cutaneous melanoma. In addition, the melanomaassociated antigen shares sequence homology with a number of transmembrane proteins that appear to be involved in growth regulation. The implication of the biological function of this ocular melanoma-associated antigen, its relevance to the malignant phenotype, and clinical applications of the molecular characterization of this melanoma-associated antigen are described.


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