To examine the potential association of central serous chorioretinopathy with endogenous hypercortisolism (Cushing's syndrome).
Ophthalmologic survey of consecutively admitted patients with endogenous Cushing's syndrome.
An eye clinic of a research center (National Eye Institute, Bethesda, Md).
Sixty consecutive patients with confirmed endogenous Cushing's syndrome.
Main Outcome Measures:
Findings from complete ophthalmologic evaluation.
Three (5%) of 60 patients had one or more episodes of appropriately documented central serous chorioretinopathy. In all cases, the episodes occurred during the period of hypercortisolism.
Central serous chorioretinopathy is an uncommon manifestation of endogenous Cushing's syndrome. Since central serous chorioretinopathy has been associated with other hypercortisolemic states, we suggest that glucocorticoids may play a role in the development of this disease.