The surgical technique described here using AnastoClip VCS was successful in fixating a posterior-chamber IOL to the iris in this laboratory model. AnastoClip VCS is used in arteriovenous access grafting, vascular repair, peripheral bypass grafting, and fistula surgical procedures with documented improved patency and reduced rates of revision. This can be attributed to the fact that the clips are inert and do not actually puncture the vessel wall; hence, they cause no inflammation or necrosis of the tissues at the clip site.16 These clips were originally designed for blood vessel anastomoses, but have also been used successfully in ureter and bile duct anastomoses.17 AnastoClip VCS has several different designs. The design that was used here is model 4000-05, the smallest size. The cartridge measures approximately 3 mm in width and holds 40 clips (Figure 4). Each clip measures approximately 0.9 mm in width and weighs 0.46 mg. Of note, a 3-piece posterior-chamber IOL suitable for iris fixation such as the model used in this study measures approximately 24.5 mg, making a pair of clips less than 5% of the total weight on the iris. Therefore, pseudophakodonesis or distortion of the pupil in cases where the clip was applied appropriately would be unlikely. There is a potential risk of corneal endothelial damage over time but it would be unlikely considering the positioning of the clips, especially in the absence of any intraocular inflammation or chemical changes in the material itself. Use of titanium has been studied extensively in the field of medicine. It is generally considered a permanent, inert material with no concerns regarding long-term toxicity or durability. In the field of ophthalmology, titanium has been used as a part of the Boston keratoprosthesis locking mechanism since March 2004 (Claes Dohlman, MD, PhD, oral communication, March 24, 2009). To date, no reports of any adverse effects have been encountered regarding the titanium ring that serves as the locking mechanism.