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A New Look at the Retinal Pigment Epithelium and Its Neighbors FREE

Arnall Patz, MD
Arch Ophthalmol. 1985;103(12):1794-1795. doi:10.1001/archopht.1985.01050120028014
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The status of the eye in both healthy and diseased states depends to a great extent on the behavior of its cellular constituents. The behavior of these cells is in a dynamic state determined in part by the intrinsic nature of the individual cell type and in part by a multitude of signals impinging on the cell. There is currently a great effort among biomedical scientists to understand the way in which these external stimuli affect cell behavior. Two important types of signals that affect cellular behavior are those derived from the extracellular matrix surrounding the cell and those derived from other cells within the vicinity of the responding cell. In the latter case, cells send signals to one another that modify their individual and aggregate behavior. Some of these cell-cell interactions are addressed by two pioneer studies published in this issue of the Archives.1,2 These studies begin to

REFERENCES

Glaser BM, Campochiaro PA, David JL Jr, et al:  Retinal pigment epithelial cells release an inhibitor of neovascularization . Arch Ophthalmol 1985;;103:1870-1875.
Campochiaro PA, Glaser BM:  Endothelial cells release a chemoattractant for retinal pigment epithelial cells in vitro . Arch Ophthalmol 1985;;103:1876-1880.
Kalebic T, Garbisa S, Glaser BM, et al:  Basement membrane collagen: Degradation by migrating endothelial cells . Science 1983;;281:281-283.
Vidaurri-Leal J, Hohman R, Glaser BM:  Effect of vitreous on morphologic characteristics of retinal pigment epithelial cells: A new approach to the study of proliferative vitreoretinopathy . Arch Ophthalmol 1984;;102:1220-1223.
Viduarri-Leal J, Glaser BM:  Effect of fibrin on morphologic characteristics of retinal pigment epithelial cells . Arch Ophthalmol 1984;;102:1376-1379.
Campochiaro PA, Jerdan JA, Glaser BM:  Serum contains chemoattractants for human retinal pigment epithelial cells . Arch Ophthalmol 1984;;102:1830-1833.
Campochiaro PA, Glaser BM:  Platelet-derived growth factor is chemotactic for human retinal pigment epithelial cells . Arch Ophthalmol 1985;;103:576-579.
Rowen SL, Glaser BM:  Retinal pigment epithelial cells release a chemoattractant for astrocytes . Arch Ophthalmol 1985;;103:704-707.

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Glaser BM, Campochiaro PA, David JL Jr, et al:  Retinal pigment epithelial cells release an inhibitor of neovascularization . Arch Ophthalmol 1985;;103:1870-1875.
Campochiaro PA, Glaser BM:  Endothelial cells release a chemoattractant for retinal pigment epithelial cells in vitro . Arch Ophthalmol 1985;;103:1876-1880.
Kalebic T, Garbisa S, Glaser BM, et al:  Basement membrane collagen: Degradation by migrating endothelial cells . Science 1983;;281:281-283.
Vidaurri-Leal J, Hohman R, Glaser BM:  Effect of vitreous on morphologic characteristics of retinal pigment epithelial cells: A new approach to the study of proliferative vitreoretinopathy . Arch Ophthalmol 1984;;102:1220-1223.
Viduarri-Leal J, Glaser BM:  Effect of fibrin on morphologic characteristics of retinal pigment epithelial cells . Arch Ophthalmol 1984;;102:1376-1379.
Campochiaro PA, Jerdan JA, Glaser BM:  Serum contains chemoattractants for human retinal pigment epithelial cells . Arch Ophthalmol 1984;;102:1830-1833.
Campochiaro PA, Glaser BM:  Platelet-derived growth factor is chemotactic for human retinal pigment epithelial cells . Arch Ophthalmol 1985;;103:576-579.
Rowen SL, Glaser BM:  Retinal pigment epithelial cells release a chemoattractant for astrocytes . Arch Ophthalmol 1985;;103:704-707.

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