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January 1987, Vol 105, No. 1 >
ARTICLE | January 1987

Corneal Immunoglobulin Deposition in the Posterior Stroma: Title and subTitle BreakA Case Report Including Immunohistochemical and Ultrastructural Observations FREE

Naguib H. Yassa, MD; Ramon L. Font, MD; Ben S. Fine, MD; Bruce H. Koffler, MD
[+] Author Affiliations

Accepted for publication June 5, 1986.

The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.

Reprint requests to Cullen Eye Institute, Baylor College of Medicine, Houston, TX 77030 (Dr Font).


Arch Ophthalmol. 1987;105(1):99-103. doi:10.1001/archopht.1987.01060010105040
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• Corneal buttons from a patient with bilateral, central, deeply located white corneal deposits that resembled the clinical description of filiform dystrophy were examined by means of light microscopy, immunohistochemistry, and electron microscopy. With light microscopy, the acidophilic fusiform deposits were seen to be oriented parallel to the stromal lamellae and were mostly in the pre-Descemet region. Immunohistochemical studies disclosed that the stromal lesions stained positively for IgG and γ light chain. With electron microscopy, the immunoglobulin deposits within the deep corneal stroma appeared to be locally synthesized by the keratocytes. Recent examination of the patient's serum failed to disclose dysproteinemia.

REFERENCES

1 +
Palm E:  A case of crystal deposits in the cornea: Precipitation of a spontaneously crystallizing plasma globulin . Acta Ophthalmol 1947;;25:165-174.
2 +
Palm E:  A case of crystal deposits in the cornea: Precipitation of a spontaneously crystallizing plasma globulin . Acta Ophthalmol 1947;;25:165-174.
3 +
Palm E:  A case of crystal deposits in the cornea: Precipitation of a spontaneously crystallizing plasma globulin . Acta Ophthalmol 1947;;25:165-174.
4 +
Oglesby RB:  Corneal opacities in a patient with cryoglobulinemia and reticulohistiocytosis . Arch Ophthalmol 1961;;65:63-66.
5 +
Aronson S, Shaw R:  Corneal crystals in multiple myeloma . Arch Ophthalmol 1959;;61:541-546.
6 +
François J:  Paraproteinaemic thesaurismosis of the cornea in Kahler's multiple myelomatosis . Ear Nose Throat J 1967;;46:857-867.
7 +
Miller KW, Green WR, Stark WJ, et al:  Immunoprotein deposition in the cornea . Ophthalmology 1980;;87:944-950.
8 +
Barr CC, Gelender H, Font RL:  Corneal crystalline deposits associated with dysproteinemia: Report of two cases and review of the literature . Arch Ophthalmol 1980;;98:884-889.
9 +
Eiferman RA, Rodrigues MM:  Unusual superficial stromal corneal deposits in IgG monoclonal gammopathy . Arch Ophthalmol 1980;;98:78-81.
10 +
Rodrigues MM, Krachmer JH, Miller SD, et al:  Posterior corneal crystalline deposits in benign monoclonal gammopathy: A clinicopathologic case report . Arch Ophthalmol 1979;;97:124-128.
11 +
Klintworth GK, Bredehoeft SJ, Reed JW:  Analysis of corneal crystalline deposits in multiple myeloma . Am J Ophthalmol 1978;;86:303-313.
12 +
Curran RE, Kenyon KR, Green WR:  PreDescemet's membrane corneal dystrophy . Am J Ophthalmol 1974;;77:711-716.
13 +
Duke-Elder S, Leigh AG:  Diseases of the outer eye , in Duke-Elder S (ed): System of Ophthalmology . St Louis, CV Mosby Co, 1973;, vol 8, pp 950-951.
14 +
Jackson WB, Gilmore NJ:  Ocular immunology: A review (first of two parts) . Can J Ophthalmol 1981;;16:3-9.
15 +
Rahi AHS, Garner A: Immunopathology of the Eye . Philadelphia, JB Lippincott, 1976;.
16 +
Laibson PR, Damiano VV:  X-ray and electron diffraction of ocular and bone marrow crystals in paraproteinemia . Science 1969;;163:581-583.
17 +
Ogelsby RB:  Corneal opacities in a patient with cryoglobulinemia and reticulohistiocytosis . Arch Ophthalmol 1961;;65:63-66.
18 +
Grayson M, Wilbrandt H:  Pre-Descemet dystrophy . Am J Ophthalmol 1967;;64:276-282.
19 +
Fernandez-Sasso D, Acosta JEP, Malbran E:  Punctiform and polychromatic pre-Descemet's dominant corneal dystrophy . Br J Ophthalmol 1979;;63:336.
20 +
Strachan IM, Maclean H:  Posterior polymorphous dystrophy of the cornea . Br J Ophthalmol 1968;;52:270-272.
21 +
Fine BS, Fine S, Peacock GR, et al:  Preliminary observations on ocular effects of highpower continuous CO2 laser irradiation . Am J Ophthalmol 1967;;64:209-222.
22 +
Lande MA, Birk DE, Nagpal ML, et al:  Phagocytic ties of human keratocyte cultures . Invest Ophthalmol Vis Sci 1981;;20:481-489.

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1 +
Palm E:  A case of crystal deposits in the cornea: Precipitation of a spontaneously crystallizing plasma globulin . Acta Ophthalmol 1947;;25:165-174.
2 +
Palm E:  A case of crystal deposits in the cornea: Precipitation of a spontaneously crystallizing plasma globulin . Acta Ophthalmol 1947;;25:165-174.
3 +
Palm E:  A case of crystal deposits in the cornea: Precipitation of a spontaneously crystallizing plasma globulin . Acta Ophthalmol 1947;;25:165-174.
4 +
Oglesby RB:  Corneal opacities in a patient with cryoglobulinemia and reticulohistiocytosis . Arch Ophthalmol 1961;;65:63-66.
5 +
Aronson S, Shaw R:  Corneal crystals in multiple myeloma . Arch Ophthalmol 1959;;61:541-546.
6 +
François J:  Paraproteinaemic thesaurismosis of the cornea in Kahler's multiple myelomatosis . Ear Nose Throat J 1967;;46:857-867.
7 +
Miller KW, Green WR, Stark WJ, et al:  Immunoprotein deposition in the cornea . Ophthalmology 1980;;87:944-950.
8 +
Barr CC, Gelender H, Font RL:  Corneal crystalline deposits associated with dysproteinemia: Report of two cases and review of the literature . Arch Ophthalmol 1980;;98:884-889.
9 +
Eiferman RA, Rodrigues MM:  Unusual superficial stromal corneal deposits in IgG monoclonal gammopathy . Arch Ophthalmol 1980;;98:78-81.
10 +
Rodrigues MM, Krachmer JH, Miller SD, et al:  Posterior corneal crystalline deposits in benign monoclonal gammopathy: A clinicopathologic case report . Arch Ophthalmol 1979;;97:124-128.
11 +
Klintworth GK, Bredehoeft SJ, Reed JW:  Analysis of corneal crystalline deposits in multiple myeloma . Am J Ophthalmol 1978;;86:303-313.
12 +
Curran RE, Kenyon KR, Green WR:  PreDescemet's membrane corneal dystrophy . Am J Ophthalmol 1974;;77:711-716.
13 +
Duke-Elder S, Leigh AG:  Diseases of the outer eye , in Duke-Elder S (ed): System of Ophthalmology . St Louis, CV Mosby Co, 1973;, vol 8, pp 950-951.
14 +
Jackson WB, Gilmore NJ:  Ocular immunology: A review (first of two parts) . Can J Ophthalmol 1981;;16:3-9.
15 +
Rahi AHS, Garner A: Immunopathology of the Eye . Philadelphia, JB Lippincott, 1976;.
16 +
Laibson PR, Damiano VV:  X-ray and electron diffraction of ocular and bone marrow crystals in paraproteinemia . Science 1969;;163:581-583.
17 +
Ogelsby RB:  Corneal opacities in a patient with cryoglobulinemia and reticulohistiocytosis . Arch Ophthalmol 1961;;65:63-66.
18 +
Grayson M, Wilbrandt H:  Pre-Descemet dystrophy . Am J Ophthalmol 1967;;64:276-282.
19 +
Fernandez-Sasso D, Acosta JEP, Malbran E:  Punctiform and polychromatic pre-Descemet's dominant corneal dystrophy . Br J Ophthalmol 1979;;63:336.
20 +
Strachan IM, Maclean H:  Posterior polymorphous dystrophy of the cornea . Br J Ophthalmol 1968;;52:270-272.
21 +
Fine BS, Fine S, Peacock GR, et al:  Preliminary observations on ocular effects of highpower continuous CO2 laser irradiation . Am J Ophthalmol 1967;;64:209-222.
22 +
Lande MA, Birk DE, Nagpal ML, et al:  Phagocytic ties of human keratocyte cultures . Invest Ophthalmol Vis Sci 1981;;20:481-489.

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