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ARTICLE |

Leukotrienes in Aqueous Humor of Patients With Uveitis FREE

Daniel V. Alfaro
Arch Ophthalmol. 1987;105(4):457-457. doi:10.1001/archopht.1987.01060040027011
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To the Editor.  —I question the conclusions made by Parker and colleagues1 in their recent article about leukotrienes in the aqueous humor of patients with uveitis. Using radioimmunoassay and column chromatographic techniques, the authors measured concentrations of leukotriene (LT) B4 and LTC4/D4/E4 in the aqueous humor of 14 patients with uveitis and seven patients without uveitis. Leukotriene B4 was detected in 11 of 14 patients with uveitis (mean, 0.96 pmol/mL), and LTC4/D4/E4 was found in 12 of 14 patients with uveitis (mean, 0.96 pmol/mL). In the control group, LTB4 was detected in six of seven patients (mean, 0.57 pmol/mL), and LTC4/D4/E4 was also found in six of seven patients (mean, 1.9 pmol/mL). They found no correlation between the LT level and clinically assessed aqueous cell and flare.The authors concluded that the

REFERENCES

Parker JA, Goetzl EJ, Friedlaender MH:  Leukotrienes in the aqueous humor of patients with uveitis . Arch Ophthalmol 1986;;104:722-724.
Czarnetzki BM, Tosenbach T:  Chemotaxis of human neutrophils and eosinophils towards leukotriene B, and its 20-ω-oxidation products in vitro . Prostaglandins 1986;;31:851-858.
Makino H, Ashida Y, Saijo T, et al:  Role of leukotrienes in rat reversed passive Arthus pleurisy and effect of AA-861, a 5-lipoxygenase inhibitor . Int Arch Allergy Appl Immunol 1986;;79:38-44.
Smith MHJ, Ford-Hutchinson AW, Bray MA: Leukotriene B:  A potential mediator of inflammation . J Pharm Pharmacol 1980;;32:517-518.
Bhattacherjee P, Eakins KE, Hammond E:  Chemotactic activity of arachidonic acid lipoxygenase products in the rabbit eye . Br J Pharmacol 1981;;73:254-257.

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Parker JA, Goetzl EJ, Friedlaender MH:  Leukotrienes in the aqueous humor of patients with uveitis . Arch Ophthalmol 1986;;104:722-724.
Czarnetzki BM, Tosenbach T:  Chemotaxis of human neutrophils and eosinophils towards leukotriene B, and its 20-ω-oxidation products in vitro . Prostaglandins 1986;;31:851-858.
Makino H, Ashida Y, Saijo T, et al:  Role of leukotrienes in rat reversed passive Arthus pleurisy and effect of AA-861, a 5-lipoxygenase inhibitor . Int Arch Allergy Appl Immunol 1986;;79:38-44.
Smith MHJ, Ford-Hutchinson AW, Bray MA: Leukotriene B:  A potential mediator of inflammation . J Pharm Pharmacol 1980;;32:517-518.
Bhattacherjee P, Eakins KE, Hammond E:  Chemotactic activity of arachidonic acid lipoxygenase products in the rabbit eye . Br J Pharmacol 1981;;73:254-257.

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