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January 1988, Vol 106, No. 1 >
ARTICLE | January 1988

Cellular Proliferation After Experimental Glaucoma Filtration Surgery FREE

Henry D. Jampel, MD; Lorraine J. B. McGuigan, MD; Greg R. Dunkelberger, MS; Nancy L. L'Hernault, MA; Harry A. Quigley, MD
[+] Author Affiliations

Accepted for publication Aug 13, 1987.

Presented in part at the Annual Meeting of the Association for Research in Vision and Ophthalmology, Sarasota, Fla, May 8, 1987.

Reprint requests to Maumenee B-110, The Johns Hopkins University Hospital, 600 N Wolfe St, Baltimore, MD 21205 (Dr Quigley).


Arch Ophthalmol. 1988;106(1):89-94. doi:10.1001/archopht.1988.01060130095036
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• We used light microscopic autoradiography to determine the time course of cellular incorporation of tritiated thymidine (a correlate of cell division) following glaucoma filtration surgery in seven eyes of four cynomolgus monkeys with experimental glaucoma. Incorporation of tritiated thymidine was detected as early as 24 hours postoperatively. Peak incorporation occurred five days postoperatively and had returned to baseline levels by day 11. Cells incorporating tritiated thymidine included keratocytes, episcleral cells, corneal and capillary endothelial cells, and conjunctival and corneal epithelial cells. Transmission electron microscopy was correlated with the autoradiographic results to demonstrate that fibroblasts were dividing on the corneoscleral margin. These findings have potential clinical implications for the use of antiproliferative agents after filtration surgery.

REFERENCES

1 +
Friedenwald JS:  Some problems in the diagnosis and treatment of glaucoma . Am J Ophthalmol 1950;;33:1523-1538.
2 +
Addicks EM, Quigley HA, Green WR, et al:  Histologic characteristics of filtering blebs in glaucomatous eyes . Arch Ophthalmol 1983;;101:795-798.
3 +
Gressel MG, Parrish RK, Folberg R:  5-Fluorouracil and glaucoma filtering surgery: I. An animal model . Ophthalmology 1984;;91:378-383.
4 +
Heuer DK, Parrish RK, Gressel MG, et al:  5-Fluorouracil and glaucoma filtering surgery: II. A pilot study . Ophthalmology 1984;;91:384-394.
5 +
Assil KK, Weinreb RN:  Multivesicular liposomes: Sustained release of the antimetabolite cytarabine in the eye . Arch Ophthalmol 1987;;105:400-403.
6 +
Skuta GL, Assil K, Parrish RK, et al:  Filtering surgery in owl monkeys treated with the antimetabolite 5-fluorouridine 5′monophosphate entrapped in multivesicular liposomes . Am J Ophthalmol 1987;;103:714-716.
7 +
Weinreb RN:  Adjusting the dose of 5-fluorouracil after filtration surgery to minimize side effects . Ophthalmology 1987;;94:564-570.
8 +
Gaasterland D, Kupfer C:  Experimental glaucoma in the rhesus monkey . Invest Ophthalmol Vis Sci 1974;;13:455-457.
9 +
Quigley HA, Hohman R:  Laser energy levels for trabecular meshwork damage in the primate eye . Invest Ophthalmol Vis Sci 1983;;24:1305-1307.
10 +
McGuigan LJB, Mason R, Sánchez R, et al:  D-Penicillamine and β-aminoproprionitrile effects on experimental filtering surgery . Invest Ophthalmol Vis Sci 1987;;28:1625-1629.
11 +
Mason RP, Quigley HA, Hohman R:  Experimental glaucoma-filtering surgery in primates . Invest Ophthalmol Vis Sci 1987;;24( (suppl) ):87.
12 +
Desjardins DC, Parrish RK, Folberg R, et al:  Wound healing after filtering surgery in owl monkeys . Arch Ophthalmol 1986;;104:1835-1839.
13 +
Treffers WF:  Human corneal endothelial wound repair: In vitro and in vivo . Ophthalmology 1982;;89:605-613.
14 +
Gloor BP, Gloor ML, Marshall J, et al:  Healing of mechanical wounds of the corneal endothelium of rhesus monkeys and rabbits , in Trevor-Roper PD (ed): The Cornea in Health and Disease . New York, Grune & Stratton, 1981;, pp 97-102.
15 +
Folkman J, Klagsbrun M:  Angiogenic factors . Science 1987;;235:442-447.
16 +
Leibovich SJ, Ross R:  The role of the macrophage in wound repair: A study with hydrocortisone and antimacrophage serum . Am J Pathol 1975;;78:71-89.
17 +
Michels RG, Kenyon KR, Maumenee AE:  Retrocorneal fibrous membrane . Invest Ophthalmol Vis Sci 1972;;11:822-831.
18 +
Dvorak HF:  Tumors: Wounds that do not heal: Similarities between tumor stroma generation and wound healing . N Engl J Med 1986;;315:1650-1659.
19 +
Jampel HD, McGuigan LJ, Pepose JS, et al:  Biology of experimental glaucoma-filtering surgery failure . Invest Ophthalmol Vis Sci 1987;;28( (suppl) ):378.

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1 +
Friedenwald JS:  Some problems in the diagnosis and treatment of glaucoma . Am J Ophthalmol 1950;;33:1523-1538.
2 +
Addicks EM, Quigley HA, Green WR, et al:  Histologic characteristics of filtering blebs in glaucomatous eyes . Arch Ophthalmol 1983;;101:795-798.
3 +
Gressel MG, Parrish RK, Folberg R:  5-Fluorouracil and glaucoma filtering surgery: I. An animal model . Ophthalmology 1984;;91:378-383.
4 +
Heuer DK, Parrish RK, Gressel MG, et al:  5-Fluorouracil and glaucoma filtering surgery: II. A pilot study . Ophthalmology 1984;;91:384-394.
5 +
Assil KK, Weinreb RN:  Multivesicular liposomes: Sustained release of the antimetabolite cytarabine in the eye . Arch Ophthalmol 1987;;105:400-403.
6 +
Skuta GL, Assil K, Parrish RK, et al:  Filtering surgery in owl monkeys treated with the antimetabolite 5-fluorouridine 5′monophosphate entrapped in multivesicular liposomes . Am J Ophthalmol 1987;;103:714-716.
7 +
Weinreb RN:  Adjusting the dose of 5-fluorouracil after filtration surgery to minimize side effects . Ophthalmology 1987;;94:564-570.
8 +
Gaasterland D, Kupfer C:  Experimental glaucoma in the rhesus monkey . Invest Ophthalmol Vis Sci 1974;;13:455-457.
9 +
Quigley HA, Hohman R:  Laser energy levels for trabecular meshwork damage in the primate eye . Invest Ophthalmol Vis Sci 1983;;24:1305-1307.
10 +
McGuigan LJB, Mason R, Sánchez R, et al:  D-Penicillamine and β-aminoproprionitrile effects on experimental filtering surgery . Invest Ophthalmol Vis Sci 1987;;28:1625-1629.
11 +
Mason RP, Quigley HA, Hohman R:  Experimental glaucoma-filtering surgery in primates . Invest Ophthalmol Vis Sci 1987;;24( (suppl) ):87.
12 +
Desjardins DC, Parrish RK, Folberg R, et al:  Wound healing after filtering surgery in owl monkeys . Arch Ophthalmol 1986;;104:1835-1839.
13 +
Treffers WF:  Human corneal endothelial wound repair: In vitro and in vivo . Ophthalmology 1982;;89:605-613.
14 +
Gloor BP, Gloor ML, Marshall J, et al:  Healing of mechanical wounds of the corneal endothelium of rhesus monkeys and rabbits , in Trevor-Roper PD (ed): The Cornea in Health and Disease . New York, Grune & Stratton, 1981;, pp 97-102.
15 +
Folkman J, Klagsbrun M:  Angiogenic factors . Science 1987;;235:442-447.
16 +
Leibovich SJ, Ross R:  The role of the macrophage in wound repair: A study with hydrocortisone and antimacrophage serum . Am J Pathol 1975;;78:71-89.
17 +
Michels RG, Kenyon KR, Maumenee AE:  Retrocorneal fibrous membrane . Invest Ophthalmol Vis Sci 1972;;11:822-831.
18 +
Dvorak HF:  Tumors: Wounds that do not heal: Similarities between tumor stroma generation and wound healing . N Engl J Med 1986;;315:1650-1659.
19 +
Jampel HD, McGuigan LJ, Pepose JS, et al:  Biology of experimental glaucoma-filtering surgery failure . Invest Ophthalmol Vis Sci 1987;;28( (suppl) ):378.

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