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January 1993, Vol 111, No. 1 >
ARTICLE | January 1993

Predictive Factors for Endothelial Cell Loss After Penetrating Keratoplasty FREE

David C. Musch, MPH, PhD; Roger F. Meyer, MD; Alan Sugar, MD, MS
[+] Author Affiliations

Accepted for publication August 17, 1992.

Presented in part at the Annual Spring Meeting of the Association for Research in Vision and Ophthalmology, Sarasota, Fla, May 3, 1992.

Reprint requests to Department of Ophthalmology, The University of Michigan, W. K. Kellogg Eye Center, 1000 Wall St, Ann Arbor, MI 48105 (Dr Musch).


Arch Ophthalmol. 1993;111(1):80-83. doi:10.1001/archopht.1993.01090010084031
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References
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• To assess the influence of donor age, donor endothelial cell density, recipient age, and diagnosis on loss of endothelial cell density after penetrating keratoplasty, we evaluated endothelial cell density data from specular endothelial images collected during the follow-up of penetrating keratoplasty surgeries performed from 1980 through 1985 at one center. Uni variate and multivariate analyses of information from 265 grafts showed consistent and statistically significant associations between 1-year postoperative loss of endothelial cell density and donor age, donor endothelial cell density, and recipient age. Corneas obtained from older donors, corneas with higher donor endothelial cell density, and corneas transplanted to older recipients demonstrated greater percentage of loss of endothelial cell density 1 year after surgery. These three factors accounted for 17% of the total variance in percentage of loss of endothelial cell density 1 year after surgery.

REFERENCES

1 +
Vogt A.  Die sichtbarkeit des lebenden hornhautendothels: ein beitrag zur methodik der spaltlampenmikroskopie . Graefes Arch Clin Exp Ophthalmol . 1920;;101:123-144.
2 +
Maurice DM.  Cellular membrane activity in the corneal endothelium of the intact eye . Experientia . 1968;;24:1094-1095.
3 +
Brown N.  Macrophotography of the anterior segment of the eye . Br J Ophthalmol . 1970;;54:697-701.
4 +
Laing RA, Sandstrom MM, Leibowitz HM.  In vivo photomicrography of the corneal endothelium . Arch Ophthalmol . 1975;;93:143-145.
5 +
Bourne WM, Kaufman HE.  Specular microscopy of human corneal endothelium in vivo . Am J Ophthalmol . 1976;;81:319-323.
6 +
Hoffer KJ.  Corneal decompensation after corneal endothelium cell count . Am J Ophthalmol . 1979;;87:252-253.
7 +
Waring GO III, Bourne WM, Edelhauser HF, Kenyon KR.  The corneal endothelium: normal and pathologic structure and function . Ophthalmology . 1982;;89:531-590.
8 +
Burns RR, Bourne WM, Brubaker RF.  Endothelial function in patients with cornea guttata . Invest Ophthalmol Vis Sci . 1981;;20:77-85.
9 +
Bourne WM, Kaufman HE.  The endothelium of clear corneal transplants . Arch Ophthalmol . 1976;;94:1730-1732.
10 +
Bourne WM, O'Fallon WM.  Endothelial cell loss during penetrating keratoplasty . Am J Ophthalmol . 1978;;85:760-766.
11 +
Bourne WM.  One-year observation of transplanted human corneal endothelium . Ophthalmology . 1980;;87:673-679.
12 +
Bourne WM.  Reduction of endothelial cell loss during phakic penetrating keratoplasty . Am J Ophthalmol . 1980;;89:787-790.
13 +
Sperling S.  Endothelial cell density in donor corneas . Acta Ophthalmol . 1980;;58:278-282.
14 +
Culbertson WW, Abbott RL, Forster RK.  Endothelial cell loss in penetrating keratoplasty . Ophthalmology . 1982;;89:600-604.
15 +
Bourne WM.  Morphologic and functional evaluation of the endothelium of transplanted human corneas . Trans Am Ophthalmol Soc . 1983;;81:403-450.
16 +
Matsuda M, Bourne WM.  Long-term morphologic changes in the endothelium of transplanted corneas . Arch Ophthalmol . 1985;;103:1343-1346.
17 +
Singh G, Bohnke M, von Domarus D, Draeger J.  Endothelial cell densities in corneal donor material . Ann Ophthalmol . 1985;;17:627-631.
18 +
Musch DC, Meyer RF, Sugar A, Vine AK.  Retinal detachment following penetrating keratoplasty . Arch Ophthalmol . 1986;;104:1617-1620.
19 +
Hirst LW, Stark WJ.  Clinical specular microscopy of corneal endothelial rejection . Arch Ophthalmol . 1983;;101:1387-1391.
20 +
Musch DC, Schwartz AE, Fitzgerald-Shelton K, Sugar A, Meyer RF.  The effect of allograft rejection after penetrating keratoplasty on central endothelial cell density . Am J Ophthalmol . 1991;;111:739-742.
21 +
Bourne WM, Doughman DJ, Lindstrom RL.  Organ-cultured corneal endothelium in vivo . Arch Ophthalmol . 1977;;95:1818-1819.
22 +
Ruusuvaara P.  Effects of corneal preservation, donor age, cadaver time and postoperative period on the graft endothelium: a specular microscopic study . Acta Ophthalmol . 1979;;57:868-881.
23 +
Rao GN, Waldron WR, Aquavella JV.  Morphology of graft endothelium and donor age . Br J Ophthalmol . 1980;;64:523-527.
24 +
Olsen T.  Post-operative changes in the endothelial cell density of corneal grafts . Acta Ophthalmol . 1981;;59:863-870.
25 +
Linn JG Jr, Stuart JC, Warnicki JW, Sinclair RA, Marsh GM.  Endothelial morphology in long-term keratoconus corneal transplants . Ophthalmology . 1981;;88:761-770.
26 +
Abbott RL, Fine M, Guillet E.  Long-term changes in corneal endothelium following penetrating keratoplasty: a specular microscopic study . Ophthalmology . 1983;;90:676-685.
27 +
Lundh BL, Kallmark B.  Endothelial cell density after penetrating keratoplasty using long-time banked donor material after long distance transportation (Denmark-Sweden) . Acta Ophthalmol . 1986;;64:492-498.
28 +
Zacks CM, Abbott RL, Fine M.  Long-term changes in corneal endothelium after keratoplasty: a follow-up study . Cornea . 1990;;9:92-97.

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1 +
Vogt A.  Die sichtbarkeit des lebenden hornhautendothels: ein beitrag zur methodik der spaltlampenmikroskopie . Graefes Arch Clin Exp Ophthalmol . 1920;;101:123-144.
2 +
Maurice DM.  Cellular membrane activity in the corneal endothelium of the intact eye . Experientia . 1968;;24:1094-1095.
3 +
Brown N.  Macrophotography of the anterior segment of the eye . Br J Ophthalmol . 1970;;54:697-701.
4 +
Laing RA, Sandstrom MM, Leibowitz HM.  In vivo photomicrography of the corneal endothelium . Arch Ophthalmol . 1975;;93:143-145.
5 +
Bourne WM, Kaufman HE.  Specular microscopy of human corneal endothelium in vivo . Am J Ophthalmol . 1976;;81:319-323.
6 +
Hoffer KJ.  Corneal decompensation after corneal endothelium cell count . Am J Ophthalmol . 1979;;87:252-253.
7 +
Waring GO III, Bourne WM, Edelhauser HF, Kenyon KR.  The corneal endothelium: normal and pathologic structure and function . Ophthalmology . 1982;;89:531-590.
8 +
Burns RR, Bourne WM, Brubaker RF.  Endothelial function in patients with cornea guttata . Invest Ophthalmol Vis Sci . 1981;;20:77-85.
9 +
Bourne WM, Kaufman HE.  The endothelium of clear corneal transplants . Arch Ophthalmol . 1976;;94:1730-1732.
10 +
Bourne WM, O'Fallon WM.  Endothelial cell loss during penetrating keratoplasty . Am J Ophthalmol . 1978;;85:760-766.
11 +
Bourne WM.  One-year observation of transplanted human corneal endothelium . Ophthalmology . 1980;;87:673-679.
12 +
Bourne WM.  Reduction of endothelial cell loss during phakic penetrating keratoplasty . Am J Ophthalmol . 1980;;89:787-790.
13 +
Sperling S.  Endothelial cell density in donor corneas . Acta Ophthalmol . 1980;;58:278-282.
14 +
Culbertson WW, Abbott RL, Forster RK.  Endothelial cell loss in penetrating keratoplasty . Ophthalmology . 1982;;89:600-604.
15 +
Bourne WM.  Morphologic and functional evaluation of the endothelium of transplanted human corneas . Trans Am Ophthalmol Soc . 1983;;81:403-450.
16 +
Matsuda M, Bourne WM.  Long-term morphologic changes in the endothelium of transplanted corneas . Arch Ophthalmol . 1985;;103:1343-1346.
17 +
Singh G, Bohnke M, von Domarus D, Draeger J.  Endothelial cell densities in corneal donor material . Ann Ophthalmol . 1985;;17:627-631.
18 +
Musch DC, Meyer RF, Sugar A, Vine AK.  Retinal detachment following penetrating keratoplasty . Arch Ophthalmol . 1986;;104:1617-1620.
19 +
Hirst LW, Stark WJ.  Clinical specular microscopy of corneal endothelial rejection . Arch Ophthalmol . 1983;;101:1387-1391.
20 +
Musch DC, Schwartz AE, Fitzgerald-Shelton K, Sugar A, Meyer RF.  The effect of allograft rejection after penetrating keratoplasty on central endothelial cell density . Am J Ophthalmol . 1991;;111:739-742.
21 +
Bourne WM, Doughman DJ, Lindstrom RL.  Organ-cultured corneal endothelium in vivo . Arch Ophthalmol . 1977;;95:1818-1819.
22 +
Ruusuvaara P.  Effects of corneal preservation, donor age, cadaver time and postoperative period on the graft endothelium: a specular microscopic study . Acta Ophthalmol . 1979;;57:868-881.
23 +
Rao GN, Waldron WR, Aquavella JV.  Morphology of graft endothelium and donor age . Br J Ophthalmol . 1980;;64:523-527.
24 +
Olsen T.  Post-operative changes in the endothelial cell density of corneal grafts . Acta Ophthalmol . 1981;;59:863-870.
25 +
Linn JG Jr, Stuart JC, Warnicki JW, Sinclair RA, Marsh GM.  Endothelial morphology in long-term keratoconus corneal transplants . Ophthalmology . 1981;;88:761-770.
26 +
Abbott RL, Fine M, Guillet E.  Long-term changes in corneal endothelium following penetrating keratoplasty: a specular microscopic study . Ophthalmology . 1983;;90:676-685.
27 +
Lundh BL, Kallmark B.  Endothelial cell density after penetrating keratoplasty using long-time banked donor material after long distance transportation (Denmark-Sweden) . Acta Ophthalmol . 1986;;64:492-498.
28 +
Zacks CM, Abbott RL, Fine M.  Long-term changes in corneal endothelium after keratoplasty: a follow-up study . Cornea . 1990;;9:92-97.

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