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Rifabutin Use in Inflammatory Bowel Disease FREE

King W. To, MD; William G. Tsiaras, MD; Walter R. Thayer, MD
Arch Ophthalmol. 1995;113(11):1354-1354. doi:10.1001/archopht.1995.01100110014002
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In the September 1994 issue of the Archives, Dr Saran and colleagues1 reported the association of acute hypopyon uveitis in patients with acquired immunodeficiency syndrome (AIDS) who had been treated for systemic Mycobacterium avium complex infection with rifabutin. Other investigators2-4 have also noted an association of uveitis with rifabutin use in their patients with human immunodeficiency virus infection.

In this country, rifabutin has been approved for only a handful of uses, such as the prophylactic treatment for disseminated M avium complex infections in patients with advanced AIDS. Other approved uses for this drug include treatment of refractory cases of pulmonary tuberculosis and inflammatory bowel disease (IBD).

We would like to share our experience with the use of rifabutin in the treatment of IBD. Ten years ago, one of us (W.R.T.) noted that when a Mycobacterium species that was isolated from the diseased bowels of two patients with Crohn's

REFERENCES

Saran BR, Maquire AM, Nichols C, et al.  Hypopyon uveitis in patients with acquired immunodeficiency syndrome treated for systemic Mycobacterium avium complex infection with rifabutin . Arch Ophthalmol . 1994;;112:1159-1165.
Siegel FP, Eilbott D, Burger H, et al.  Dose-limiting toxicity of rifabutin in AIDS-related complex syndrome of arthraligia/arthritis . AIDS . 1991;;4:433-441.
Shafran SD, Deschenes J, Miller M, et al.  The MAC study group of the Canadian HIV trials network: uveitis and pseudojaundice during a regimen of clarithromycin, rifabutin and ethambutol . N Engl J Med . 1994;;330:438-439.
Jacobs DS, Piliero PJ, Kuperwaser MG, et al.  Acute uveitis associated with rifabutin use in patients with human immunodeficiency virus infection . Am J Ophthalmol . 1994;;118:716-722.
Chiodini RJ, Van Kruiningen HJ, Thayer WR, et al.  Possible role of Mycobacteria in inflammatory bowel disease, I: an unclassified Mycobacterium species isolated from patients with Crohn's disease . Dig Dis Sci . 1984;;29:1073-1079.
Thayer WR, Coutu JA, Chiodini RJ, et al.  Possible role of Mycobacteria in inflammatory bowel disease, II: mycobacterial antibodies in Crohn's disease . Dig Dis Sci . 1984;;29:1080-1085.
Thayer WR, Coutu J, Chiodini R, et al.  Use of rifabutin and streptomycin in the therapy of Crohn's disease: preliminary results . In: MacDermott RP, ed. Inflammatory Bowel Disease . Amsterdam, the Netherlands: Elsevier Science Publishers BV; 1988;:565-568.

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Saran BR, Maquire AM, Nichols C, et al.  Hypopyon uveitis in patients with acquired immunodeficiency syndrome treated for systemic Mycobacterium avium complex infection with rifabutin . Arch Ophthalmol . 1994;;112:1159-1165.
Siegel FP, Eilbott D, Burger H, et al.  Dose-limiting toxicity of rifabutin in AIDS-related complex syndrome of arthraligia/arthritis . AIDS . 1991;;4:433-441.
Shafran SD, Deschenes J, Miller M, et al.  The MAC study group of the Canadian HIV trials network: uveitis and pseudojaundice during a regimen of clarithromycin, rifabutin and ethambutol . N Engl J Med . 1994;;330:438-439.
Jacobs DS, Piliero PJ, Kuperwaser MG, et al.  Acute uveitis associated with rifabutin use in patients with human immunodeficiency virus infection . Am J Ophthalmol . 1994;;118:716-722.
Chiodini RJ, Van Kruiningen HJ, Thayer WR, et al.  Possible role of Mycobacteria in inflammatory bowel disease, I: an unclassified Mycobacterium species isolated from patients with Crohn's disease . Dig Dis Sci . 1984;;29:1073-1079.
Thayer WR, Coutu JA, Chiodini RJ, et al.  Possible role of Mycobacteria in inflammatory bowel disease, II: mycobacterial antibodies in Crohn's disease . Dig Dis Sci . 1984;;29:1080-1085.
Thayer WR, Coutu J, Chiodini R, et al.  Use of rifabutin and streptomycin in the therapy of Crohn's disease: preliminary results . In: MacDermott RP, ed. Inflammatory Bowel Disease . Amsterdam, the Netherlands: Elsevier Science Publishers BV; 1988;:565-568.

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