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Latanoprost and Hyperpigmentation of Eyelashes FREE

Martin Wand, MD
Arch Ophthalmol. 1997;115(9):1206-1208. doi:10.1001/archopht.1997.01100160376025
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Latanoprost (Xalatan, Pharmacia Upjohn Co, Kalamazoo, Mich) is the first new class of antiglaucoma medication introduced in 20 years. Initial reports about its ocular hypotensive effects seem to be promising, but it has an intriguing side effect of increasing iris pigmentation. On a theoretical basis, hyperpigmentation of periocular structures also

REFERENCES

Alm A, Stjernschnatz J, Scandanavian Latanoprost Study Group.  Effects on intraocular pressure and side effects of 0.005% latanoprost applied once daily, evening or morning . Ophthalmology . 1995;;102:1743-1752.
Watson P, Stjernschantz J,  Latanoprost Study Group. A six-month, randomized, double-masked study comparing latanoprost with timolol in open-angle glaucoma and ocular hypertension . Ophthalmology . 1996;;103:126-137.
Camras CB, the United States Latanoprost Study Group.  Comparison of latanoprost and timolol in patients with ocular hypertension and glaucoma . Ophthalmology . 1996;;103:138-147.
Camras CB, Alm A, Watson P, et al.  Latanoprost, a prostaglandin analog, for glaucoma therapy: efficacy and safety after 1 year of treatment in 198 patients . Ophthalmology . 1996;;103:1916-1924.
Kang S, Sober AJ.  Disturbances of melanin pigmentation . In: Moschella SL, Marley MJ, eds. Dermatology . 3rd ed. Philadelphia, Pa: WB Saunders Co; 1992;:1442-1474.
Nordlund JJ.  Introduction to the biology at the pigment system . In: Moschella SL, Marley MJ, eds. Dermatology . 3rd ed. Philadelphia, Pa: WB Saunders Co; 1992;:1421-1441.
Abdel-Malek ZA, Swope VB, Amornsiripanitch N, et al.  In vitro modulation of proliferation and melanization of S91 melanoma cells by prostaglandins . Cancer Res . 1987;;47:3141-3146.
Nordlund JJ, Collins CE, Rheins LA.  Prostaglandins E2 and D2 but not MSH stimulate the proliferation of pigment cells in the pinnal epidermis of DBA/2 mouse . J Invest Dermatol . 1986;;86:433-437.
Hadley ME, Levine N.  Hormonal control of melanogenesis . In: Levine N, ed. Pigmentation and Pigmentary Disorders . Boca Raton, Fla: CRC Press Inc; 1993;:95-114.
Arnoult L, Bowman ZL, Kimbrough RL, et al.  Periocular cutaneous pigmentary changes associated with topical betaxolol . J Glaucoma . 1995;;4:263-267.
Jakubovic HR, Ackerman AB.  Structure and function of skin: development, morphology and physiology . In: Moschella SL, Marley MJ, eds. Dermatology . 3rd ed. Philadelphia, Pa: WB Saunders Co; 1992;:24-29.
Prota G. Melanins and Melanogenesis . Orlando, Fla: Academic Press Inc; 1952;.
Westerhof W, Nanninga PB.  Graying of hair in humans: morphological biological data . In: Bergdorf WMC, Katz SI, eds. Dermatology: Progress and Perspectives . Pearl River, NY: Parthenon Publishing Group Inc; 1993;:508-512.

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Alm A, Stjernschnatz J, Scandanavian Latanoprost Study Group.  Effects on intraocular pressure and side effects of 0.005% latanoprost applied once daily, evening or morning . Ophthalmology . 1995;;102:1743-1752.
Watson P, Stjernschantz J,  Latanoprost Study Group. A six-month, randomized, double-masked study comparing latanoprost with timolol in open-angle glaucoma and ocular hypertension . Ophthalmology . 1996;;103:126-137.
Camras CB, the United States Latanoprost Study Group.  Comparison of latanoprost and timolol in patients with ocular hypertension and glaucoma . Ophthalmology . 1996;;103:138-147.
Camras CB, Alm A, Watson P, et al.  Latanoprost, a prostaglandin analog, for glaucoma therapy: efficacy and safety after 1 year of treatment in 198 patients . Ophthalmology . 1996;;103:1916-1924.
Kang S, Sober AJ.  Disturbances of melanin pigmentation . In: Moschella SL, Marley MJ, eds. Dermatology . 3rd ed. Philadelphia, Pa: WB Saunders Co; 1992;:1442-1474.
Nordlund JJ.  Introduction to the biology at the pigment system . In: Moschella SL, Marley MJ, eds. Dermatology . 3rd ed. Philadelphia, Pa: WB Saunders Co; 1992;:1421-1441.
Abdel-Malek ZA, Swope VB, Amornsiripanitch N, et al.  In vitro modulation of proliferation and melanization of S91 melanoma cells by prostaglandins . Cancer Res . 1987;;47:3141-3146.
Nordlund JJ, Collins CE, Rheins LA.  Prostaglandins E2 and D2 but not MSH stimulate the proliferation of pigment cells in the pinnal epidermis of DBA/2 mouse . J Invest Dermatol . 1986;;86:433-437.
Hadley ME, Levine N.  Hormonal control of melanogenesis . In: Levine N, ed. Pigmentation and Pigmentary Disorders . Boca Raton, Fla: CRC Press Inc; 1993;:95-114.
Arnoult L, Bowman ZL, Kimbrough RL, et al.  Periocular cutaneous pigmentary changes associated with topical betaxolol . J Glaucoma . 1995;;4:263-267.
Jakubovic HR, Ackerman AB.  Structure and function of skin: development, morphology and physiology . In: Moschella SL, Marley MJ, eds. Dermatology . 3rd ed. Philadelphia, Pa: WB Saunders Co; 1992;:24-29.
Prota G. Melanins and Melanogenesis . Orlando, Fla: Academic Press Inc; 1952;.
Westerhof W, Nanninga PB.  Graying of hair in humans: morphological biological data . In: Bergdorf WMC, Katz SI, eds. Dermatology: Progress and Perspectives . Pearl River, NY: Parthenon Publishing Group Inc; 1993;:508-512.

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