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In their article about a Hispanic KERA mutation in the September 2005 issue of the ARCHIVES, Ebenezer et al1 discussed previously reported KERA mutations in a Finnish cohort,2 a Chinese-American patient,2 and a Bangladeshi family.3 They described KERA as encoding 10 conserved leucine-rich regions (LRRs) and stated that previously reported KERA mutations associated with autosomal recessive cornea plana affect 1 of these LRRs.
Ebenezer and colleagues did not reference the nonsense KERA mutation (CGA313→TGA) reported in an affected Saudi Arabian family in June 2004,4 and they misstated the number of LRRs that KERA contains. This Saudi mutation is predicted to cause premature protein truncation in exon 3, an exon responsible for coding 2 LRRs not recognized by Ebenezer and colleagues. Human KERA was originally described as encoding 11 LRRs—10 in exon 2 and 1 in exon 3.5 Thereafter, the number of LRRs coded by exon 3 was recognized as 2 rather than 1, making the total number of KERA LRRs 12.6
Correspondence: Dr Khan, Department of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, PO Box 7191, Riyadh 11462, Saudi Arabia (arif.khan@mssm.edu).
Financial Disclosure: None reported.
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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